Author

D. Otzen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Organism:mouse· 1

Frequent Co-Authors

A. Moellebjerg· 1 shared B. Y. Lee· 1 shared C. T. Filice· 1 shared C. Thiesen· 1 shared D. Valyuk· 1 shared E. V. Pavlov· 1 shared G. A. S. Minero· 1 shared G. F. Amodeo· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperMicrobiology

A. Moellebjerg

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Extracellular G-quadruplex and Z-DNA protect biofilms from DNase I and forms a DNAzyme with peroxidase activity

G. A. S. Minero, A. Moellebjerg, C. Thiesen, M. I. Johansen, N. P. Joergensen, V. Birkedal, D. Otzen, R. L. Meyer

This study identifies non-canonical DNA structures like G-quadruplex and Z-DNA in staphylococcal biofilms that protect against DNase I and confer peroxidase activity to eDNA.

bioRxiv · May 22, 2023 · PreprintMicrobiology

Polarized α-synuclein trafficking and transcytosis across Brain Endothelial Cells via Rab7-decorated carriers

P. Alam, M. R. Holst, L. Laursen, J. Nielsen, S. Nielsen, J. Brewer, P. H. Jensen, D. Otzen, M. S. Nielsen

This study identifies Rab7-decorated carriers mediating polarized transcytosis of monomeric α-synuclein across brain endothelial cells, suggesting Rab7 as a therapeutic target for Parkinson's disease.

bioRxiv · Dec 21, 2021Cell Biology

C subunit of the ATP synthase is an amyloidogenic channel-forming peptide: possible implications in mitochondrial pathogenesis

G. F. Amodeo, B. Y. Lee, N. Krilyuk, C. T. Filice, D. Valyuk, D. Otzen, S. Noskov, Z. Leonenko, E. V. Pavlov

This study identifies the c subunit of ATP synthase as an amyloidogenic peptide that forms ion channels and may contribute to mitochondrial toxicity through mechanisms similar to neurodegenerative proteins.

bioRxiv · Jan 16, 2020 · PreprintBiophysics