Identification of Pre-Existing Adaptive Immunity to Cas9 Proteins in Humans
C. T. Charlesworth, P. S. Deshpande, D. P. Dever, B. Dejene, N. Gomez-Ospina, S. Mantri, M. Pavel-Dinu, J. Camarena, K. I. Weinberg, M. H. Porteus
The paper detects pre-existing adaptive immunity to Cas9 proteins in humans, finding antibodies against both SaCas9 and SpCas9 and T-cells specific to SaCas9.
bioRxiv · Jan 5, 2018Immunology