Author

M. H. Porteus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:genetic perturbation / CRISPR· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. Pavel-Dinu· 3 shared Y. Nakauchi· 2 shared A. Awani· 1 shared A. DeVilbiss· 1 shared A. K. Amaya· 1 shared A. Sheikali· 1 shared B. Dejene· 1 shared B. Palterer· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersImmunology

M. Pavel-Dinu

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cell BiologyMolecular Biology of the CellPeer-reviewedFeb 1, 2024

Small molecule correctors divert CFTR-F508del from ERAD by stabilizing sequential folding states

C. Riepe, M. Wachalska, K. K. Deol…·R. R. Kopito

The paper identifies molecular machinery underlying CFTR-F508del ERAD and shows correctors stabilize RNF5-resistant folding states.

DOI 10.1091/mbc.e23-08-0336

humanexperimental assay

𝕏 PostBluesky

ImmunologybioRxivJul 12, 2022

Genetically Corrected RAG2-SCID Human Hematopoietic Stem CellsRestore V(D)J-Recombinase and Rescue Lymphoid Deficiency

M. Pavel-Dinu, C. L. Gardner, Y. Nakauchi…·M. H. Porteus

This study corrects the RAG2 gene in human hematopoietic stem cells to restore V(D)J recombination and lymphoid development in RAG2-SCID patients.

DOI 10.1182/bloodadvances.2023011766

𝕏 PostBluesky

Cell BiologybioRxivPreprintJul 5, 2021

Reticular Dysgenesis-associated Adenylate Kinase 2 deficiency causes failure of myelopoiesis through disordered purine metabolism

W. Wang, A. DeVilbiss, M. Arreola…·K. G. Weinacht

This study shows AK2 deficiency disrupts mitochondrial metabolism, causing purine metabolism disorder and myelopoiesis failure through AMP accumulation and NAD+ depletion.

DOI 10.1101/2021.07.05.450633

𝕏 PostBluesky

ImmunologybioRxivJan 5, 2018

Identification of Pre-Existing Adaptive Immunity to Cas9 Proteins in Humans

C. T. Charlesworth, P. S. Deshpande, D. P. Dever…·M. H. Porteus

The paper detects pre-existing adaptive immunity to Cas9 proteins in humans, finding antibodies against both SaCas9 and SpCas9 and T-cells specific to SaCas9.

DOI 10.1038/s41591-018-0326-x

humanproteomics

𝕏 PostBluesky