ImmunologybioRxiv
Identification of Pre-Existing Adaptive Immunity to Cas9 Proteins in Humans
C. T. Charlesworth, P. S. Deshpande, D. P. Dever…·M. H. Porteus
The paper detects pre-existing adaptive immunity to Cas9 proteins in humans, finding antibodies against both SaCas9 and SpCas9 and T-cells specific to SaCas9.
DOI 10.1038/s41591-018-0326-x