Author

D. Parthasarathy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:experimental assay· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Herschhorn· 2 shared M. Harris· 2 shared D. Mazurov· 1 shared H. C. Benet· 1 shared H. Cervera Benet· 1 shared J. Jeffy· 1 shared J. Sodroski· 1 shared K. Janowska· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersMicrobiology

A. Herschhorn

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2 papers

Recent·Most cited

Alternative substitutions of N332 in HIV-1AD8 gp120 differentially affect envelope glycoprotein function and viral sensitivity to broadly neutralizing antibodies targeting the V3-glycan

J. Jeffy, D. Parthasarathy, S. Ahmed, H. Cervera Benet, U. Xiong, M. Harris, D. Mazurov, S. Pickthorn, A. Herschhorn

This study examines how different amino acids at position 332 of HIV-1AD8 gp120 affect viral sensitivity to antibodies, cold exposure, and infectivity.

bioRxiv · Nov 20, 2023 · PreprintMicrobiology

Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted / founder sensitivity to broadly neutralizing antibodies

D. Parthasarathy, K. R. Pothula, K.-M. A. Dam, S. Ratnapriya, H. C. Benet, R. Parsons, X. Huang, S. Sammour, K. Janowska, M. Harris, S. Sacco, J. Sodroski, M. Bridges, W. Hubbell, P. Acharya, A. Herschhorn

This paper shows that some HIV-1 transmitted/founder Envs are incompletely closed, making them sensitive to antibodies targeting open conformations, and highlights the importance of Env conformational flexibility for bnAb neutralization.

bioRxiv · Sep 13, 2023Microbiology