A. Herschhorn

Alternative substitutions of N332 in HIV-1AD8 gp120 differentially affect envelope glycoprotein function and viral sensitivity to broadly neutralizing antibodies targeting the V3-glycan

This study examines how different amino acids at position 332 of HIV-1AD8 gp120 affect viral sensitivity to antibodies, cold exposure, and infectivity.

Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted / founder sensitivity to broadly neutralizing antibodies

This paper shows that some HIV-1 transmitted/founder Envs are incompletely closed, making them sensitive to antibodies targeting open conformations, and highlights the importance of Env conformational flexibility for bnAb neutralization.

Ultrasensitive quantification of HIV-1 cell-to-cell transmission in primary human CD4+ T cells measures viral sensitivity to broadly neutralizing antibodies

Detecting sources of immune activation and viral rebound in HIV infection

The paper compares assays for detecting HIV-producing cells and p24 during ART to identify sources of immune activation and viral rebound.

Conformation of HIV-1 Envelope governs rhesus CD4 usage and simian-human immunodeficiency virus replication

This paper shows that open conformation of HIV-1 Env allows efficient use of rhesus CD4 and enhances SHIV replication in rhesus macaques.

Intra- and extra-cellular environments contribute to the fate of HIV-1 infection

The paper develops a system to monitor HIV-1 fate and shows that both intracellular and extracellular environments in BLT humanized mice influence HIV-1 infection outcomes.