Ophiobolin A Covalently Targets Complex IV Leading to Mitochondrial Metabolic Collapse in Cancer Cells
F. A. Gowans, D. Q. Thach, Y. Wang, B. E. A. Poblano, D. Dovala, J. A. Tallarico, J. M. McKenna, M. Schirle, T. J. Maimone, D. K. Nomura
This study identifies Ophiobolin A's covalent targets in complex IV of mitochondria, revealing a mechanism of metabolic collapse and cell death in cancer cells.
bioRxiv · Mar 9, 2023Biochemistry