Author

F. A. Gowans

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

B. E. A. Poblano· 2 shared D. K. Nomura· 2 shared Y. Wang· 2 shared D. Dovala· 1 shared D. Q. Thach· 1 shared I. E. Wertz· 1 shared J. A. Tallarico· 1 shared J. Hatcher· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

B. E. A. Poblano

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2 papers

Recent·Most cited

Covalent Degrader of the Oncogenic Transcription Factor β-Catenin

F. A. Gowans, N. Forte, J. Hatcher, O. W. Huang, Y. Wang, B. E. A. Poblano, I. E. Wertz, D. K. Nomura

This paper identifies a covalent degrader, EN83, that targets and degrades β-catenin by covalently binding to four cysteine residues, demonstrating a strategy to overcome the 'undruggable' challenge of transcription factors.

bioRxiv · Oct 31, 2023Biochemistry

Ophiobolin A Covalently Targets Complex IV Leading to Mitochondrial Metabolic Collapse in Cancer Cells

F. A. Gowans, D. Q. Thach, Y. Wang, B. E. A. Poblano, D. Dovala, J. A. Tallarico, J. M. McKenna, M. Schirle, T. J. Maimone, D. K. Nomura

This study identifies Ophiobolin A's covalent targets in complex IV of mitochondria, revealing a mechanism of metabolic collapse and cell death in cancer cells.

bioRxiv · Mar 9, 2023Biochemistry