Cancer BiologybioRxivPreprint
SPOP mutation confers sensitivity to AR-targeted therapy in prostate cancer by reshaping the androgen-driven chromatin landscape
I. Grbesa, M. A. Augello, D. Liu…·C. E. Barbieri
This study shows that SPOP mutations in prostate cancer alter the chromatin landscape and AR-driven transcription, making tumors more responsive to AR-targeted therapies.