D. Liu

Genomic heterogeneity and ploidy identify patients with intrinsic resistance to PD-1 blockade in metastatic melanoma

This study identifies genomic heterogeneity and ploidy as markers of intrinsic resistance to PD-1 blockade in metastatic melanoma, with a decision tree model predicting resistance with high confidence.

BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health

This study shows that HSCs produce BMP9/10, which regulate KCs and ECs to maintain liver homeostasis, and their deletion leads to fibrosis and iron overload.

Identifying individuals at risk for surgical supravalvar aortic stenosis by polygenic risk score with graded phenotyping

The paper develops polygenic risk scores for surgical supravalvar aortic stenosis using variants from Williams syndrome patients, achieving high AUC and low misclassification rates.

High-throughput drug screening for inhibition of influenza A virus infection based on human SIRT1 promoter and Genipin suppressing influenza A virus by activation of AMPK-SIRT1-PGC-1α signaling pathway

This study identifies Genipin and its derivatives as inhibitors of influenza A virus replication by activating the AMPK-SIRT1-PGC-1α signaling pathway and altering metabolic reprogramming.

High-plex spatial RNA imaging in one round with conventional microscopes using color-intensity barcodes

This paper introduces PRISM, a method for high-plex spatial RNA imaging using color intensity barcodes, validated across multiple tissues and showing the role of CAFs in tumor microenvironments.

Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma

The paper identifies a mature dendritic cell subtype associated with improved immune response and prognosis in melanoma patients treated with anti-PD-1 checkpoint inhibitors.

Unveiling the mechanisms of black phosphorus nanosheets-induced viable but non-culturable state in Bacillus tropicus

This study investigates how black phosphorus nanosheets induce a viable but non-culturable state in Bacillus tropicus, revealing suppressed metabolism and respiratory pathways as key mechanisms.

High glucose treatment induced nuclei aggregation of microvascular endothelial cells via foxo1a-klf2a pathway

This study shows high glucose causes endothelial cell nuclei aggregation in zebrafish via foxo1a-klf2a pathway, linking it to microvascular complications.

Aquaporins enriched in endothelial vacuole membrane regulate the diameters of microvasculature in hyperglycemia

This study identifies aquaporins in endothelial cells that regulate microvascular diameter in hyperglycemia, suggesting they are potential targets for diabetes-related vascular therapy.

Specific oncogene activation of the cell of origin in mucosal melanoma

This study develops a zebrafish model of mucosal melanoma by activating an oncogene and inactivating tumor suppressors, revealing that internal melanocytes give rise to tumors with distinct transcriptional and chromatin features.

Nanocluster-antibody-drug conjugates (NADC) as an intravesical precision theranostic agent for interstitial cystitis

This paper develops a nanocluster-antibody-drug conjugate (NADC) for interstitial cystitis, showing it targets NGF-overexpressing bladder lesions and reduces inflammation in rat models.

Positive Selection on Rare Variants Underlying the Cold Adaptation of Wild Boar

This study identifies rare variants under positive selection in wild boar linked to cold adaptation, showing convergent molecular evolution with humans.

In-depth investigation of the mechanisms of high and low residual feed intake regulating hens during the late laying period via liver and gut microbiota.

The origin and evolution of cultivated rice and genomic signatures of heterosis for yield traits in super-hybrid rice

This study investigates the evolutionary history of cultivated rice and identifies genomic signatures of heterosis in super-hybrid rice varieties.

Granzyme B-based CAR T cells block metastasis by eliminating circulating tumor cells

This study develops GrB-CAR T cells targeting mHSP70 to eliminate CTCs and inhibit metastasis in solid tumors.

Unicellular cyanobacteria rely on sodium energetics to fix N2

This study shows that unicellular cyanobacteria rely on sodium energetics for N2 fixation, which may explain their low abundance in coastal waters due to insufficient NaCl levels.

Heterogeneous hybrid immunity against Omicron variant JN.1 at 11 months following breakthrough infection

This study evaluates hybrid immunity against the Omicron variant JN.1 11 months after breakthrough infection, showing heterogeneous responses and increased neutralization following reinfection.

Schlafen-11 and -9 are innate immune sensors for intracellular single-stranded DNA

The paper identifies Schlafen-11 and -9 as innate immune sensors that recognize intracellular single-stranded DNA containing CGT motifs, leading to cytokine expression and cell death.

Canonical AREs are tumor suppressive regulatory elements in the prostate

This study identifies canonical AREs as tumor suppressive regulatory elements in prostate cancer, showing their reactivation can induce death in AR+ cancer cells and is linked to better prognosis.

Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy

This study shows that targeting CD38 improves T cell function and restores response to immunotherapy in melanoma models.

Mitochondrial fission surveillance is coupled to Caenorhabditis elegans DNA and chromosome segregation integrity

The paper identifies genes regulating mitochondrial fission in C. elegans and shows that chromosome missegregation leads to mitochondrial fission dysregulation, independent of Drp-1.

Noncaloric monosaccharides induce excessive sprouting angiogenesis in zebrafish via foxo1a-marcksl1a signal

This study shows noncaloric monosaccharides cause excessive angiogenesis in zebrafish by activating foxo1a-marcksl1a signaling, leading to ectopic tip cell formation.

Unraveling wheat endosperm development: epigenetic regulation and novel regulators for enhanced yield and quality

This study identifies novel regulators of starch and seed storage protein biosynthesis in wheat endosperm, revealing their role in grain yield and quality through epigenetic and transcriptional mechanisms.

Simultaneous generation of osteoblasts and adipocytes by a bivalent differentiation medium from bone marrow stromal/stem cells (BMSCs)

This paper introduces a bivalent differentiation medium that enables BMSCs to simultaneously generate osteoblasts and adipocytes, with a method to assess lineage commitment using staining techniques.

Application of slow-controlled release fertilizer coordinates the carbon flow in carbon-nitrogen metabolism to effect rice quality

This study evaluates five slow-controlled release fertilizers on rice quality over two years, finding that BBF improves yield and grain quality by optimizing carbon-nitrogen metabolism.

Inhibition of KLK8 promotes pulmonary endothelial repair by restoring VE-cadherin/Akt/FOXM1 pathway

This study shows that inhibiting KLK8 restores the VE-cadherin/Akt/FOXM1 pathway, promoting endothelial repair and reducing sepsis-induced lung injury and mortality.

MICLEAR: Intelligent Molecular Cytology for Intraoperative Margin Assessment of Pancreatic Ductal Adenocarcinoma

MICLEAR uses Raman imaging and machine learning to assess PDAC surgical margins with high accuracy and speed.

Listeria adhesion protein orchestrates caveolae-mediated apical junctional remodeling of epithelial barrier for L. monocytogenes translocation

This study shows LAP promotes L. monocytogenes translocation by remodeling epithelial junctions via caveolae-mediated endocytosis.

Accurate identification of cancer cells in complex pre-clinical models using deep-learning: a transfection free approach.

ORACLE, a deep-learning model, accurately identifies ovarian cancer cells from healthy cells in 3D co-cultures using nuclear shape, outperforming existing methods.

Genetically refactored Agrobacterium-mediated transformation

This paper refactors the Agrobacterium tumor-inducing plasmid into a minimal set of genes for plant and fungal transformation, demonstrating a bottom-up engineering approach.