D. Huang

SlNAP2 promoted fruit ripening by directly binding the ACS2 promoter and interacting with EIL3

This study identifies SlNAP2 as a NAC transcription factor that promotes tomato fruit ripening by directly binding the ACS2 promoter and interacting with EIL3 to enhance ethylene signaling.

CLCC1 Governs Bilayer Equilibration at the Endoplasmic Reticulum to Maintain Cellular and Systemic Lipid Homeostasis

This study identifies CLCC1 as a key regulator of phospholipid trans-bilayer equilibration at the ER, essential for lipid homeostasis and preventing metabolic diseases.

Deciphering the Preeclampsia-Specific Immune Microenvironment: The Role of Pro-inflammatory Macrophages

This study identifies pro-inflammatory macrophages as key regulators of the PE-specific immune microenvironment, linking them to Th17 and CD8+ T cell activation and gMDSC suppression in placental tissues.

Aeromonas hydrophila CobQ is a new type of NAD+- and Zn2+-independent protein lysine deacetylase

This paper identifies AhCobQ as a novel NAD+- and Zn2+-independent lysine deacetylase in Aeromonas hydrophila with unique domain and substrate specificity.

Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4

This study reports the structures and mechanistic insights of PLD3 and PLD4, revealing their exonuclease activity, phosphatase function, and disease relevance.

Injury induced renal fibrosis promotes cystogenesis and cyst growth in adult mice with autosomal dominant polycystic kidney disease

This study shows that renal fibrosis induced by injury promotes cyst formation and growth in adult ADPKD mice, and targeting EZH2 can reduce fibrosis and cyst growth.

Mitochondrial outer membrane integrity regulates a ubiquitin-dependent NF-κB inflammatory response

This study shows that mitochondrial outer membrane permeabilization triggers ubiquitin-dependent NF-κB inflammation by recruiting NEMO to ubiquitylated mitochondria.

Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers

This study identifies and characterizes inhibitors of SMARCA4/SMARCA2 ATPases, showing their ability to induce lineage-specific chromatin changes and tumor regression in uveal melanoma.

The catalytic mechanism of the RNA methyltransferase METTL3

This study reveals the catalytic mechanism of METTL3-14 by identifying two adenosine binding conformations, the methyl transfer transition state, and the roles of key residues in catalysis.

Primed and ready: Nanopore metabarcoding can now recover highly accurate consensus barcodes that are generally indel-free

This study shows nanopore metabarcoding can produce highly accurate, indel-free consensus barcodes for community analysis, comparable to Illumina sequencing.

Rapid Prototyping of Thermoplastic Microfluidic 3D Cell Culture Devices by Creating Regional Hydrophilicity Discrepancy

This paper develops a method to rapidly prototype thermoplastic microfluidic devices for 3D cell culture by creating regional hydrophilicity discrepancies, enabling dynamic cell culture and drug screening.

Ferroptosis is determined by chloride ions

This study identifies chloride ions as essential determinants of ferroptosis, showing that extracellular chloride levels influence lipid peroxidation and cell death.

A Host-Harbored Metabolic Susceptibility of Coronavirus Enables Broad-Spectrum Targeting

The paper identifies a host metabolic pathway essential for coronavirus replication and shows that inhibiting it with Propranolol has broad antiviral effects.

The Mangrove Microbiome of the Malay Peninsula

This study examines the microbiome of mangrove trees in the Malay Peninsula, identifying a core microbiome and key taxa involved in nutrient cycling and carbon sequestration.

Multi-omics analysis identifies symbionts and pathogens of blacklegged ticks (Ixodes scapularis) from a Lyme disease hotspot in southeastern Ontario, Canada

This study uses multi-omics to analyze the microbiome of blacklegged ticks in a Lyme disease hotspot, revealing higher beta-diversity in dissected tissues and evidence of co-infection by multiple pathogens.

Regulation of interstitial fluid flow along adventitia of vasculature by heartbeat and respiration

The paper identifies a circulatory pathway for interstitial fluid flow along vasculature adventitia in rats, regulated by heartbeat and respiration.

VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis

This study shows that senescence in CD8+ T cells reduces VLA-4 expression, impairing their migration and promoting leptomeningeal metastasis in a mouse model of breast cancer.

Mass spectrometry imaging reveals early metabolic priming of cell lineage in differentiating human induced pluripotent stem cells

The paper uses mass spectrometry imaging to identify metabolic markers of lineage specification in differentiating human iPSCs, showing phospholipids as early indicators of pluripotency loss.

The high-resolution in vivo measurement of replication fork velocity and pausing by lag-time analysis

This paper introduces lag-time analysis to measure replication fork velocity and pausing in vivo, finding locus- and time-dependent dynamics and novel pauses at rDNA.

Regulation of Cardiomyocyte Adhesion and Mechanosignalling Through Distinct Nanoscale Behaviour of Integrin Ligands Mimicking Healthy or Fibrotic ECM

This study investigates how integrin-ligand combinations affect cardiomyocyte adhesion, traction forces, and mechanosignalling in healthy and fibrotic ECM environments.

Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape

This study engineers SARS-CoV-2 neutralizing antibodies through directed evolution to enhance their potency and reduce viral escape.

Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells

This study develops an organoid-based method to generate large quantities of NK cells from human pluripotent stem cells without feeder cells, achieving efficient and scalable iNK cell production.

Genome-wide H3K9 Acetylation Level Increases with Age-Dependent Senescence of Flag Leaf in Rice (Oryza sativa)

The paper investigates age-dependent H3K9 acetylation changes in rice flag leaf senescence, finding increased H3K9ac levels correlate with gene expression and identify regulatory networks.

Hoxb5 reprograms murine multipotent blood progenitors into hematopoietic stem cell-like cells

This study shows that Hoxb5 can convert multipotent blood progenitors into hematopoietic stem cell-like cells with long-term repopulating ability.

Compositional phylogenomic modelling resolves the 'Zoraptera problem': Zoraptera are sister to all other polyneopteran insects

This study resolves the Zoraptera placement in insect phylogeny, finding Zoraptera as the earliest-diverging polyneopteran order and providing a Devonian origin for winged insects.

Integrated phylogenomics and fossil data illuminate the evolution of beetles

This paper integrates phylogenomic data and fossil records to refine the evolutionary timescale and classification of beetles, revealing a late Carboniferous origin and Cretaceous diversification.

SARS-CoV-2 preS dTM vaccine booster candidates increase functional antibody responses and cross-neutralization against SARS-CoV-2 variants of concern in non-human primates

This study evaluates booster vaccine formulations in macaques, showing increased neutralizing antibodies and cross-neutralization against SARS-CoV-2 variants and SARS-CoV-1.

Legionella pneumophila regulates host cell motility by targeting Phldb2 with a 14-3-3ζ-dependent protease effector

This study identifies Lem8, a protease effector from Legionella pneumophila, which inhibits host cell motility by targeting Phldb2 via 14-3-3ζ-dependent activation.

Characterizing stochastic cell cycle dynamics in exponential growth

The paper establishes an exact correspondence between deterministic and stochastic cell cycle models, showing deterministic models can well-fit exponential culture demographics even with stochastic state timing.

Dynamic surveillance of mosquitoes and their viromes in Wuhan during 2020.

This study analyzes mosquito species and viromes in Wuhan, China, from April to October 2020, revealing seasonal changes and stable viruses in Culex mosquitoes.