The transmembrane domain of DWORF activates SERCA directly; P15 and W22 residues are essential.
A. Li, D. R. Stroik, S. L. Yuen, E. Kleinboehl, R. L. Cornea, D. D. Thomas
This study identifies key residues in DWORF that activate SERCA2a by displacing PLB, using FRET biosensors and mutagenesis.
bioRxiv · Sep 18, 2020 · PreprintBiophysics