A. Li

Spatial histomorphometry reveals that local peripheral nerves modulate but are not required for skeletal adaptation to applied load in mice

SlNAP2 promoted fruit ripening by directly binding the ACS2 promoter and interacting with EIL3

This study identifies SlNAP2 as a NAC transcription factor that promotes tomato fruit ripening by directly binding the ACS2 promoter and interacting with EIL3 to enhance ethylene signaling.

Electrostatic interactions in nucleosome and higher-order structures are regulated by protonation state of histone ionizable residue

The paper investigates how changes in histone protonation states affect nucleosome electrostatic potentials and interactions with partner proteins, and how cancer mutations influence these interactions.

Unravelling an Efficient O2/Reductant-Dependent Catalytic Route in Heme Peroxygenases for Sustainable Applications

This paper identifies an O2/reductant-dependent catalytic pathway in heme peroxygenases that avoids H2O2-induced inactivation, enabling efficient and sustainable chemical transformations.

HIGH THROUGHPUT QUANTITATION OF HUMAN NEUTROPHIL RECRUITMENT AND FUNCTIONAL RESPONSES IN AN AIR-BLOOD BARRIER ARRAY

The paper develops a high-throughput assay to study neutrophil recruitment and function in an air-blood barrier array, showing improved throughput and sample efficiency compared to existing methods.

Targeting IDH1-Mutated Oligodendroglioma with Acid Ceramidase Inhibitors

This study shows that inhibiting acid ceramidase (AC) induces apoptosis and improves survival in IDH1-mutated oligodendroglioma by increasing ceramide levels and activating both extrinsic and intrinsic apoptosis pathways.

Targeting the sphingolipid rheostat in IDH1mut glioma alters cholesterol homeostasis and triggers apoptosis via membrane degradation

This study shows that altering sphingosine levels in IDH1mut glioma cells disrupts cholesterol homeostasis, leading to apoptosis through effects on cholesterol synthesis, uptake, and efflux.

Force-Enhanced Sensitive Detection of New DNA-Interactive Agents from Microorganisms at the Single-Molecule Level

This paper introduces a single-molecule stretching assay to detect DNA-intercalating agents from microorganisms, identifying two strains and three compounds with anti-cancer activity.

All-trans retinoic acid induces durable tumor immunity in IDH-mutant gliomas by rescuing transcriptional repression of the CRBP1-retinoic acid axis

This study shows that all-trans retinoic acid (ATRA) improves immune response in IDH-mutant gliomas by restoring the RA pathway, leading to tumor regression in mouse models and a clinical trial for human patients.

Mitochondrial Raf1 Regulates Glutamine Catabolism

This paper identifies Raf1 within mitochondria where it interacts with GLS to regulate glutamine catabolism and tumorigenesis, independent of MAPK signaling.

Post-death Vesicles of Senescent Bone Marrow Mesenchymal Stromal Polyploids Promote Macrophage Aging and Breast Cancer

HER2 Prognostic Significance and Therapeutic Implications in Gastric Cardia Adenocarcinoma: Insights from Multi-Omics Profiling

This study identifies HER2 as a prognostic marker in GCA and suggests anti-inflammatory and immune checkpoint inhibition as therapeutic strategies for HER2-negative patients.

Several common methods of making vesicles (except an emulsion method) capture intended lipid ratios

This study compares lipid composition variations in vesicles made by five methods, finding significant differences in cholesterol and phospholipid ratios, particularly with emulsion transfer.

Harnessing the diversity of Burkholderia spp. prophages for therapeutic potential

The paper identifies prophages in Burkholderia spp. genomes that show lytic activity against conspecific and heterospecific isolates, suggesting their potential for phage therapy.

Biosynthesis of the proteins containing neurotoxin β-N-methylamino-L-alanine in marine diatoms

This study investigates how iron limitation increases BMAA-containing protein production in marine diatoms and identifies cysK as a key enzyme in BMAA biosynthesis.

Protein tyrosine phosphatase receptor kappa regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity

This study identifies PTPRK's role in promoting hepatocyte metabolic reprogramming in obesity by regulating glycolysis and lipogenesis, with potential therapeutic implications for obesity-related liver diseases.

Cell type-specific translational regulation by human DUS enzymes

This study identifies DUS enzymes' role in tRNA modification and shows cell type-specific effects on translation.

The LexA-RecA* structure reveals a lock-and-key mechanism for SOS activation

The paper determines the structure of the LexA-RecA* complex, revealing a lock-and-key mechanism that triggers SOS response gene induction by enabling LexA cleavage.

Unexpected delayed incursion of highly pathogenic avian influenza H5N1 (clade 2.3.4.4b) in the Antarctic region

The paper investigates the delayed incursion of H5N1 avian influenza in Antarctica by analyzing surveillance data from before confirmed cases.

HIPSD&R-seq enables scalable genomic copy number and transcriptome profiling

HIPSD&R-seq profiles genomic copy number and transcriptomes in thousands of cells, enabling rare clone detection in human cell models and primary tissue.

Transcriptome-wide RNA structure probing with temporal resolution

This paper introduces SNIPER-seq, a method to map RNA structure dynamics with temporal resolution, revealing structural changes in human 5S rRNA during ribosome biogenesis.

Identification of tumor-intrinsic drivers of immune exclusion in acral melanoma

This study identifies 11 oncogenic pathways associated with immune exclusion and ICI resistance in acral melanoma, suggesting therapeutic targets for immunotherapy combinations.

Liquid plug propagation in computer-controlled microfluidic airway-on-a-chip with semi-circular microchannels

This paper presents a lung-on-a-chip device that enables systematic study of liquid plug dynamics in distal airways, showing effects of surfactant, viscosity, and channel geometry on plug propagation and epithelial cell injury.

The phospholipid biosynthesis enzyme PlsB contains three distinct domains for membrane association, lysophosphatidic acid synthesis and dimerization

This study determines the structure of PlsB from Themomonas haemolytica using cryo-EM, revealing three domains and their roles in membrane association, catalysis, and dimerization.

Target Identification and Mechanistic Characterization of Indole Terpenoid Mimics: Proper Spindle Microtubule Assembly Is Essential for Cdh1-Mediated Proteolysis of CENP-A

The paper identifies microtubule-targeting agents that induce CENP-A accumulation by destabilizing Cdh1, linking microtubule dynamics to CENP-A proteolysis.

Metabolic Reprogramming by Histone Deacetylase Inhibition Selectively Targets NRF2-activated tumors.

The paper shows that inhibiting HDACs selectively targets NRF2-activated lung adenocarcinoma by altering chromatin and metabolic pathways.

Spatial and temporal transcriptomics of SHH-medulloblastoma with chromothripsis identifies multiple genetic clones that resist to treatment and lead to relapse

This study uses spatial transcriptomics to analyze chromothriptic medulloblastomas, revealing higher intra-tumour heterogeneity, treatment resistance, and relapse mechanisms through clone-specific features.

Isolation of ACE2-dependent and -independent sarbecoviruses from Chinese horseshoe bats

The paper isolates ACE2-dependent and -independent sarbecoviruses from Chinese horseshoe bats using a new virus isolation protocol.

The cryptic step in biogeochemical Tellurium (Te) cycle: Indirect elementary Te oxidation mediated by manganese-oxidizing bacterium (MnOB)

This paper identifies a previously overlooked process where manganese-oxidizing bacteria oxidize elemental tellurium, challenging the assumption of Te0 stability in wastewater treatment.

Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice

This study identifies distinct transcriptomic features in satellite cells of extraocular muscles that preserve neuromuscular junctions in ALS mice, suggesting potential therapeutic strategies.