Author

D. Riggs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Organism:Arabidopsis· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

R. Julian· 2 shared A. E. Loraine· 1 shared A. Kang· 1 shared B. Ford· 1 shared C. Augello· 1 shared E. Coburn· 1 shared J. Benesch· 1 shared J. Daradur· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiochemistry

R. Julian

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3 papers

Recent·Most cited

Genomic targets of HOP2 are enriched for features found at recombination hotspots

J. Daradur, M. Kesserwan, N. H. Freese, A. E. Loraine, D. Riggs

The paper identifies genomic targets of HOP2 in Arabidopsis and shows they overlap with recombination hotspots and contain conserved motifs.

bioRxiv · Jan 25, 2023 · PreprintPlant Biology

Spontaneous isomerization of long-lived proteins provides a molecular mechanism for the lysosomal failure observed in Alzheimer’s disease

T. Lambeth, D. Riggs, L. Talbert, J. Tang, E. Coburn, A. Kang, J. Noll, C. Augello, B. Ford, R. Julian

This paper shows that isomerization of long-lived proteins in Alzheimer’s disease prevents lysosomal digestion, leading to lysosomal failure and linking AD to lysosomal storage disorders.

bioRxiv · Apr 18, 2019Biochemistry

Structural and Functional Consequences of Age-Related Isomerization in α Crystallins

Y. Lyon, D. Riggs, M. Collier, M. Degiacomi, J. Benesch, R. Julian

This study investigates how isomerization of amino acids in α- and β-crystallins affects protein assembly and function, showing significant disruptions in oligomerization and phosphorylation.

bioRxiv · Jul 9, 2018Biochemistry