J. Tang

Simultaneous detection of pathogens and antimicrobial resistance genes with the open source, cloud-based, CZ ID pipeline

The paper develops an open-source, cloud-based tool for detecting pathogens and antimicrobial resistance genes in metagenomic and whole-genome sequencing data, demonstrating its application across clinical and environmental studies.

Rampant transcription replication conflict creates therapeutic vulnerability in extrachromosomal DNA containing cancers

This paper identifies transcription-replication conflict as a vulnerability in ecDNA-containing cancers and demonstrates that CHK1 inhibition selectively kills these tumors.

Spatiotemporal regulation of Pseudorabies Virus Thymidine kinase UL23 by post-translational modification

This study investigates SUMO modification of PRV UL23 and shows it affects subcellular localization but not stability.

Patient-derived functional immuno-oncology platform identifies responders to ATR inhibitor and immunotherapy combinations in ovarian cancer

Targeting transcription factors through an IMiD independent zinc finger domain

This study identifies a new IMiD-independent drug targeting SALL4's ZFC4 domain, leading to significant tumor growth inhibition in vivo.

Multi-modal microvascular cerebral blood flow velocity mapping with 14T single-vessel MRI and optical microscopy in the mouse brain

This study combines 14T single-vessel MRI and optical microscopy to map cerebral blood flow velocity in mouse brain microvessels, validating measurements across modalities.

Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses

The paper identifies two European bat MERS-related coronaviruses that use ACE2 as their receptor, revealing a distinct binding mode and host tropism determinants.

Cross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression

This study identifies SFRP1 as a therapeutic target for glioblastoma by revealing its role in reprogramming tumor methylomes and improving survival in mouse models.

Severe Osteoarthritis in Aged PANX3 Knockout Mice: Implications for a Novel Primary Osteoarthritis Model

This study shows that aged PANX3 knockout mice develop severe primary osteoarthritis, suggesting PANX3 deletion harms joint health in aging.

CRISPR-Cas12a-Based Rapid and Sensitive Detection of rpoBL378R in Mycobacterium tuberculosis

This paper develops a CRISPR-Cas12a-based detection system to identify the rpoBL378R mutation in Mycobacterium tuberculosis, showing high specificity and sensitivity for drug-resistant strains.

CRISPR-Cas9 for selective targeting of somatic mutations in pancreatic cancers

This paper demonstrates CRISPR-Cas9 can selectively target somatic mutations in pancreatic cancer by exploiting PAMs in noncoding regions, achieving >80% cell death with minimal off-target effects.

Pannexin 3 deletion in mice results in knee osteoarthritis and intervertebral disc degeneration after forced treadmill running.

This study shows that deleting Panx3 in mice leads to increased knee osteoarthritis and intervertebral disc degeneration after forced treadmill running.

A scalable, GMP-compatible, autologous organotypic cell therapy for Dystrophic Epidermolysis Bullosa

This paper develops a scalable, GMP-compatible cell therapy for Dystrophic Epidermolysis Bullosa using CRISPR-corrected iPS cells to generate functional skin grafts.

Indole produced during dysbiosis mediates host-microorganism chemical

The paper shows that indole, produced by E. coli during gut dysbiosis in C. elegans, activates DAF-16 to enhance host fitness by limiting bacterial accumulation.

Mechanical regulation of retinal vascular inflammation and degeneration in diabetic retinopathy

This study shows that retinal vascular stiffening, caused by LOX overexpression, mechanically regulates inflammation and degeneration in diabetic retinopathy, and that inhibiting LOX prevents these effects.

Genome-wide mapping of fluoroquinolone-stabilized DNA gyrase cleavage sites displays drug specific effects that correlate with bacterial persistence

The paper maps fluoroquinolone-stabilized DNA gyrase cleavage sites in E. coli and finds drug-specific effects correlating with bacterial persistence.

Highly Sensitive and Specific Amyloid-β Oligomers Detection Using CRISPR-Cas12a Probe System aided by Graphene Oxide for Early Diagnosis of Alzheimer's Diseases

This study develops a CRISPR-Cas12a-based sensor enhanced with graphene oxide for specific and sensitive detection of amyloid-β oligomers, aiming to enable early Alzheimer's disease diagnosis.

Microcirculatory dysfunction associates with neurovascular uncoupling in peri-ischemic brain regions after ischemic stroke

This study shows that arterial occlusion in mice leads to pericyte constriction and microcirculatory failure in peri-ischemic brain regions, impairing neurovascular coupling after reperfusion.

Development of allosteric, selective cyclin-dependent kinase 2 (CDK2) inhibitors that are negatively cooperative with cyclin binding and show potential as contraceptive agents

This paper develops high-affinity, structurally confirmed allosteric CDK2 inhibitors that show negative cooperativity with cyclin binding and demonstrate contraceptive potential in mouse testicular explants.

Life history strategies and niches of soil bacteria emerge from interacting thermodynamic, biophysical, and metabolic traits

The paper predicts life history traits of soil bacteria based on thermodynamic, biophysical, and metabolic traits, showing growth efficiency becomes more important later in plant growth.

The structure of the humanised A33 Fab C226S variant, an immunotherapy candidate for colorectal cancer

The paper reports the crystal structures of a humanised A33 Fab antibody variant targeting colorectal cancer, focusing on structural features of the grafted CDRs and switch linker.

Integrating inflammatory biomarker analysis and artificial intelligence-enabled image-based profiling to identify drug targets for intestinal fibrosis

The paper identifies potential drug targets for intestinal fibrosis by combining image-based morphology analysis with AI and inflammatory biomarker measurements.

A Chitin-Binding Protein Ultra-highly expressed in the Outer Fold of Mantle is Related to Shell Colour in Pacific Oyster Crassostrea gigas

This study identifies a chitin-binding protein, CgCBP, highly expressed in the outer fold of the mantle of Pacific oyster Crassostrea gigas, which is linked to shell pigmentation through its role in periostracum structure.

WNT5A-RHOA axis is a new vulnerability in small-cell lung cancer

This study identifies the WNT5A-RHOA axis as a critical driver of small-cell lung cancer, offering new therapeutic targets and insights into WNT signaling heterogeneity.

Targeting N-Myc in Neuroblastoma with Selective Aurora Kinase A Degraders

This study develops a first-in-class Aurora-A/N-Myc degrader, HLB-0532259, which effectively reduces N-Myc levels and shows tumor reduction in neuroblastoma models.

Human endogenous retrovirus activation contributes to biliary atresia pathogenesis through re-education of resident macrophages

This study identifies HERV activation in BA livers and shows it re-educates macrophages, impairing neutrophil recruitment and causing liver damage, suggesting therapeutic targets.

Generating Functional Cells Through Enhanced Interspecies Chimerism with Human Pluripotent Stem Cells

This study demonstrates that MYCN and BCL2 enhance interspecies chimerism with human pluripotent stem cells, enabling the generation of functional human blood progenitor cells in chimeric embryos.

LCK-14-3-3ζ-TRPM8 axis for regulating TRPM8 function/assembly promotes pancreatic cancer malignancy

This study identifies the LCK-14-3-3ζ-TRPM8 axis as a regulator of TRPM8 function and assembly, promoting pancreatic cancer malignancy through phosphorylation at Y1022.

Wireless closed-loop smart bandage for chronic wound management and accelerated tissue regeneration

This paper develops a wireless smart bandage that monitors wound conditions and delivers electrical stimulation to accelerate tissue regeneration in chronic wounds.

Comprehensive Analysis of Co-Mutations Identifies Cooperating Mechanisms of Tumorigenesis

The paper analyzes co-mutations across multiple cancer types to identify cooperating mechanisms in tumorigenesis and their clinical implications.