Helical ultrastructure of the oncogenic metalloprotease meprin α in complex with a small molecule hydroxamate inhibitor
C. Bayly-Jones, C. J. Lupton, C. Fritz, H. Venugopal, D. Ramsbeck, M. Wermann, C. Jager, A. de Marco, S. Schilling, D. Schlenzig, J. C. Whisstock
This study determines the high-resolution structure of meprin α, revealing its helical assembly and interactions with an inhibitor and fetuin-B, showing oligomerization enhances stability without affecting activity.
bioRxiv · Mar 13, 2022 · PreprintBiochemistry