C. Bayly-Jones

This study identifies the discontinuous quaternary neoepitope of the C9 protein in the complement C5b-9 complex using cryo-EM, revealing its formation through adjacent domains without major conformational changes.

This study determines the high-resolution structure of meprin α, revealing its helical assembly and interactions with an inhibitor and fetuin-B, showing oligomerization enhances stability without affecting activity.

This study uses single-molecule fluorescence imaging to analyze the kinetics of PFO pore formation, revealing that membrane insertion is kinetically controlled.

This paper determines the cryo-EM structure of full-length NF1, revealing its autoinhibited conformation and providing insights into disease mechanisms and therapeutic strategies.

This paper determines the structure of MPEG-1, showing it forms a pre-pore complex and can perforate membranes under acidic conditions.