B Cell Division Capacity in Germinal Centers Depends on Myc Transcript Stabilization Through m6A mRNA Methylation and IGF2BP3 Functions
A. C. Grenov, L. Moss, S. Edelheit, R. Cordiner, D. Schmiedel, A. Biram, J. H. Hanna, T. Heick Jensen, S. Schwartz, Z. Shulman
The paper shows that m6A methylation via METTL3 stabilizes Myc transcripts in germinal center B cells, which is essential for maintaining GC responses and MYC-driven lymphoma.
bioRxiv · Sep 8, 2020Immunology