M. Schwartz

A virally encoded high resolution screen of cytomegalovirus host dependencies

This study develops VECOS, a viral-encoded CRISPR screen to analyze host dependencies during cytomegalovirus infection, identifying novel factors and revealing the importance of virion assembly.

The molecular principles governing HCMV infection outcome

This study identifies molecular factors determining HCMV infection outcomes in macrophages and monocytes using single-cell transcriptomics, revealing that viral gene expression and intrinsic ISG levels dictate productive vs. non-productive infection.

Unannotated small RNA clusters in circulating extracellular vesicles detect early stage liver cancer

The paper identifies a 3-smRC signature from circulating extracellular vesicles that detects early-stage liver cancer with high sensitivity and specificity.

Mapping mitonuclear epistasis using a novel recombinant yeast population

The paper maps mitonuclear epistasis in yeast by creating a novel recombinant population and identifies loci influencing mtDNA stability and mitotic growth.

Intratumoral mregDC and CXCL13 T helper niches enable local differentiation of CD8 T cells following PD-1 blockade

The paper identifies intratumoral niches involving mregDC and CXCL13+ Th cells that support CD8 T cell differentiation following PD-1 blockade in HCC patients.

Parsing the role of NSP1 in SARS-CoV-2 infection

This study investigates the role of SARS-CoV-2 nsp1 in host shutoff and immune evasion, finding it inhibits translation and induces mRNA degradation, and is critical for counteracting the IFN response.

Temporal Dynamics of HCMV Gene Expression in Lytic and Latent Infections

This study examines HCMV gene expression dynamics during productive and latent infections, revealing that viral gene regulation is not a simple sequential cascade and that IE genes are uniquely repressed in latency.

CRISPR-Targeted CAR Gene Insertion Using Cas9/RNP and AAV6 Enhances Anti-AML Activity of Primary NK Cells

SARS-CoV-2 utilizes a multipronged strategy to suppress host protein synthesis

This study identifies how SARS-CoV-2 suppresses host protein synthesis through global translation reduction, mRNA degradation, and impaired translation of immune-related transcripts.

Vulnerability of ARID1A deficient cancer cells to pyrimidine synthesis blockade

This paper identifies ARID1A-deficient cancer cells as vulnerable to pyrimidine synthesis blockade and shows synergy between teriflunomide and AZD6738 in suppressing ARID1A-mutant tumors.

The coding capacity of SARS-CoV-2

This study maps the full coding capacity of SARS-CoV-2 using ribosome profiling, identifying 23 novel translated ORFs and revealing viral translation dominance over host translation.

Highly efficient site-directed gene insertion in primary human natural killer cells using homologous recombination and CRISPaint delivered by AAV

This paper develops a method for efficient site-directed gene insertion in primary human NK cells using CRISPaint and AAV delivery, achieving up to 89% mCherry expression.

Comprehensive Annotations of Human Herpesvirus 6A and 6B Genomes Reveal Novel and Conserved Genomic Features

This study identifies hundreds of new ORFs and lncRNAs in HHV-6A and B genomes, revealing conserved features across betaherpesviruses.

Genomic Retargeting of Tumor Suppressors p53 and CTCF Promotes Oncogenesis

The paper identifies p53 and CTCF as key regulators of transcriptional reprogramming in early oncogenic transformation driven by HRas, showing that chromatin redistribution, not expression changes, drives malignancy.

Activation of Smad 2/3 signaling by low shear stress mediates artery inward remodeling

This study shows that low shear stress activates Smad 2/3 signaling in endothelial cells, leading to inward artery remodeling.

microRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis

The paper identifies microRNA-dependent regulation of biomechanical genes that maintain tissue stiffness homeostasis through cytoskeletal and extracellular matrix control.

Defining the Transcriptional Landscape during Cytomegalovirus Latency with Single-Cell RNA Sequencing

This study uses single-cell RNA sequencing to analyze HCMV latency and finds no evidence of a restricted latency-associated gene expression program, instead showing gene expression patterns similar to late lytic stages at lower levels.