The viral SUMO-targeted Ubiquitin Ligase ICP0 is phosphorylated and activated by host kinase Chk2
D. S. Hembram, H. Negi, P. Biswas, V. Tripathi, L. Bhushan, D. Shet, V. Kumar, R. Das
This study identifies how HSV's ICP0 protein uses phosphorylation by Chk2 to activate its SUMO-targeted Ubiquitin Ligase activity against PML NBs.
bioRxiv · Jul 21, 2019Biochemistry