P. Biswas

Heme allocation in eukaryotic cells relies on mitochondrial heme export through FLVCR1b to cytosolic GAPDH

The paper identifies FLVCR1b as the mitochondrial heme exporter that delivers heme to GAPDH and downstream hemeproteins in human cells.

Visualizing Mitochondrial Heme Flow through GAPDH to Targets in Living Cells and its Regulation by NO

The paper visualizes mitochondrial heme flow through GAPDH to IDO1 in living cells and shows NO regulates heme reallocation between GAPDH and IDO1 based on NO levels.

Long-term cold selection leads to increased thermal plasticity of male body size and thermal canalization of fecundity in populations of Drosophila melanogaster

Auxin Exposure Disrupts Feeding Behavior and Fatty Acid Metabolism in Adult Drosophila

This study shows auxin exposure affects adult Drosophila feeding behavior and fatty acid metabolism but not fecundity or progeny survival.

A universal stress protein is essential for the survival of Mycobacterium tuberculosis

This study identifies Rv1636 as an essential cAMP-binding protein in Mycobacterium tuberculosis that regulates intracellular cAMP levels and is required for bacterial survival.

Indoleamine Dioxygenase and Tryptophan Dioxygenase Activities are Regulated through Control of Cell Heme Allocation by Nitric Oxide

The paper investigates how nitric oxide (NO) regulates heme allocation to IDO1 and TDO, showing a bimodal effect on their activities in mammalian cells.

Piezo1 mechanosensing regulates integrin-dependent chemotactic migration in human T cells

This study shows that Piezo1 mechanosensing is essential for integrin-dependent chemotactic migration of human T cells by mediating calcium influx and calpain activation.

Probing the role of macromolecular crowding in cell volume regulation using fluorescence anisotropy

This study investigates the role of macromolecular crowding in cell volume regulation using fluorescence anisotropy and finds that cytoplasmic MMC is not a sensor for volume regulation, while membrane tension is critical.

Regnase-1 deficiency restrains Klebsiella pneumoniae infection by regulation of a Type I interferon response

This study shows that Regnase-1 deficiency increases resistance to Klebsiella pneumoniae infection by enhancing Type I interferon responses, despite not affecting bacterial clearance or pro-inflammatory cytokine expression.

Essential Loop Dynamics Modulates Catalytic Activity in α-Chymotrypsin

This study investigates how essential loop dynamics in alpha-chymotrypsin affect its catalytic activity using optical spectroscopy and molecular dynamics simulations.

A Combined Spectroscopic and Molecular Modeling Study on Structure-Function-Dynamics under Chemical Modification: Alpha-Chymotrypsin with Formalin Preservative

This study examines how formalin modifies alpha-chymotrypsin's structure and function, showing reduced catalytic activity and altered substrate binding due to cross-linking.

Sex determination gene transformer regulates the male-female difference in Drosophila fat storage via the adipokinetic hormone pathway

The paper identifies transformer as a key gene regulating sex differences in fat storage in Drosophila by modulating the adipokinetic hormone pathway in neurons.

High CXCL6 drives matrix expression and correlate with markers of poor outcome in IPF

This study identifies CXCL6 as a pro-fibrotic factor in IPF, showing it reduces cAMP, increases collagen and -SMA, and correlates with poor patient survival.

Redox Nanomedicine Cures Chronic Kidney Disease (CKD) by Mitochondrial Reconditioning

This study demonstrates that a redox nanomedicine, C-Mn3O4 NPs, treats CKD by restoring mitochondrial function and redox balance in animal models.

Redox Buffering Capacity of Nanomaterials as an Index of ROS-based Therapeutics and Toxicity: A Preclinical Animal Study

This study evaluates the redox buffering capacity of nanomaterials to assess their therapeutic potential and toxicity in a preclinical animal model.

Incorporation of a Biocompatible Nanozyme in Cellular Antioxidant Enzyme Cascade Reverses Huntington's Like Disorder in Preclinical Model

This paper demonstrates that a biocompatible nanozyme can reverse Huntington's-like disorder in a preclinical model by mimicking glutathione peroxidase and integrating into the cellular antioxidant cascade.

The viral SUMO-targeted Ubiquitin Ligase ICP0 is phosphorylated and activated by host kinase Chk2

This study identifies how HSV's ICP0 protein uses phosphorylation by Chk2 to activate its SUMO-targeted Ubiquitin Ligase activity against PML NBs.

Larval growth and survival in Indian Butter Catfish, Ompok bimaculatus (Bloch): effect of light intensity and photoperiod

This study examines how light intensity and photoperiod affect growth and survival of Ompok bimaculatus larvae, finding optimal conditions for growth and survival.

Nitric oxide sensing by chlorophyll a

The paper proposes using chlorophyll a to sense and classify different nitric oxide species with high sensitivity and temperature dependence.