V. Kumar

JAX Animal Behavior System (JABS): A genetics informed, end-to-end advanced behavioral phenotyping platform for the laboratory mouse

The paper introduces JABS, a platform for automated behavioral phenotyping in mice, integrating data acquisition, machine learning, and genetic analysis to improve behavior classification and genetic studies.

Heat-killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide promote longevity by modulating aging hallmarks and enhancing immune responses in Caenorhabditis elegans

This study shows that heat-killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide extend C. elegans lifespan by improving proteostasis and immune responses through modulation of insulin-like signaling, autophagy-lysosome pathway, and antioxidant defenses.

Histologic variants in bladder cancer harbor aggressive molecular features including TM4SF1 expression and a CA125+ cell state

Single cell RNA sequencing of bladder cancer subtypes identified a CA125+ cell state linked to aggressive features and TM4SF1 as a therapeutic target.

Biological activities and metabolic profile of endophytic Bacillus haynesii from Momordica charantia

This study evaluates the antioxidant and anti-inflammatory potential of an endophytic Bacillus haynesii from Momordica charantia and identifies its bioactive metabolites.

Exploring Probiotic Potential: A Comparative Genomics and In Silico Assessment of Genes within the Genus Geobacillus

This study assesses the probiotic potential of Geobacillus by analyzing its genomic features, revealing safety traits and absence of virulence factors.

The evolutionary history and functional specialization of microRNA genes in Arabidopsis halleri and A. lyrata

This study investigates the evolutionary history and functional specialization of miRNA genes in Arabidopsis halleri and A. lyrata, showing rapid birth-and-death dynamics and integration into core biological processes.

Dominance modifiers at the Arabidopsis self-incompatibility locus retain proto-miRNA features and act through non-canonical pathways

The paper investigates sRNA precursors at the Arabidopsis self-incompatibility locus, showing they repress recessive alleles through non-canonical pathways and generate diverse sRNA molecules.

Impact of Species-Specific Plant Growth-Promoting Rhizobacteria (PGPR) on Maize (Zea mays) Phenotypic and Biochemical Diversity

This study evaluates the impact of four PGPR species on maize growth and biochemical parameters, finding significant increases in chlorophyll, enzymes, and yield.

Population genomics reveals demographic history and climate adaptation in Japanese Arabidopsis halleri

This study uses population genomics to analyze climate adaptation and demographic history in Japanese Arabidopsis halleri, revealing genetic differentiation and selection signatures linked to climate variables.

Sse1, Hsp110 chaperone of yeast, controls the cellular fate during Endoplasmic Reticulum-stress

This study shows that Sse1, a yeast Hsp110 chaperone, interacts with ER-UPR sensors and regulates ER protein homeostasis, ribosome reorganization, and cell division arrest during ER stress.

UDP-6-glucose dehydrogenase in hormonally responsive breast cancers

This study shows that UGDH knockdown reduces estrogen-induced tumorigenic traits in breast cancer models and validates findings in human clinical specimens.

Learning Continuous 2D Diffusion Maps from Particle Trajectories without Data Binning

The paper develops a Bayesian method using Gaussian Processes to map diffusion coefficients continuously across membranes from particle trajectories without data binning.

P66Shc Mediates SUMO2-induced Endothelial Dysfunction

This study identifies SUMO2-mediated modification of p66Shc as a mechanism causing endothelial dysfunction and oxidative stress in hyperlipidemia.

Evolution of human pair bonds as a consequence of male-biased mating sex ratios?

The paper models the evolution of human pair bonds by simulating male mating strategies under different sex ratio conditions and finds that higher sex ratios favor mate-guarding over multiple mating.

Drosophila Asap regulates cellular protrusions via dArf6-dependent actin regulatory pathway

This study shows that dAsap regulates membrane protrusions in Drosophila S2R+ cells through Arf6 inactivation via its ArfGAP domain and re-localization of actin regulators.

Prognostic relevance of correlated co-expression of coding and noncoding RNAs in cervical cancers

The paper identifies prognostically relevant co-expression patterns between coding and noncoding RNAs in HPV16-positive cervical cancers and links them to patient survival.

Whole Genome Sequencing and Assembly of the House Sparrow, Passer domesticus

The paper provides a high-quality whole genome sequence and assembly for the house sparrow, Passer domesticus, which serves as a reference for comparative and population genomic studies.

Senescence of endplate osteoclasts induces sensory innervation and spinal pain

This study identifies senescent osteoclasts in spinal models as contributors to pain through nerve growth and vessel formation, showing their removal reduces hypersensitivity.

The stress-induced lincRNA JUNI is a critical factor for cancer cell survival whose interactome is a prognostic signature in clear cell renal cell carcinoma

This paper identifies JUNI, a stress-induced lncRNA critical for cancer cell survival, and shows its interactome predicts prognosis in clear cell renal cell carcinoma.

Cooperative activities of dICA69 N-BAR and dCIP4 F-BAR domain proteins regulate membrane tubule organization in vivo

This study shows that dICA69 N-BAR and dCIP4 F-BAR domains cooperate to regulate membrane tubule organization in vivo through coordinated recruitment and redistribution.

Beyond Traditional Methods: Innovative Integration of LISS IV and Sentinel 2A Imagery for Unparalleled Insight into Himalayan Ibex Habitat Suitability

This study integrates LISS IV and Sentinel 2A satellite data with machine learning to improve habitat suitability mapping for Himalayan Ibex, achieving high classification accuracy and identifying key environmental factors.

Cardiomyocyte-specific adenylyl cyclase type-8 overexpression induces activation of RelA together with myocardial and systemic inflammation

This study shows that overexpressing adenylyl cyclase type-8 in cardiomyocytes activates RelA and causes myocardial and systemic inflammation, leading to accelerated aging and reduced lifespan.

Analytical Method Development for Evaluation of Pharmacokinetics and Tissue Distribution of Thiourea-Based Antivirals through nLC/MS-MS

The paper develops a sensitive nLC-MS/MS method to quantify thiourea derivatives in plasma and tissues of rats, showing good linearity and precision.

Safety Assessment and Evaluation of Novel Thiourea Derivatives as Antivirals

This paper evaluates the safety of three thiourea derivatives (DSA-00, DSA-02, DSA-09) as antivirals, finding they are non-cytotoxic, non-mutagenic, and have moderate acute toxicity.

Chemical inhibition of histidine biosynthesis curtails M. tuberculosis infection

This study designs triazole inhibitors targeting M. tuberculosis's histidine biosynthesis pathway, showing efficacy against drug-resistant strains and reducing bacterial burden in infected mice.

Leveraging RAS-mSIN1 Interaction to Selectively Inhibit mTORC2 Employing Competitive RAS Binding Peptide: Implications in Breast Cancer Metastasis

The paper withdraws a manuscript due to incomplete experiments and requests that it not be cited as a reference.

Acetyl transferase EP300 deficiency leads to chronic replication stress mediated by defective fork protection at stalled replication forks

This paper shows that EP300 deficiency causes chronic replication stress and genomic instability in ATLL cells by impairing fork protection and leading to DNA damage and mitotic defects.

HLA topography enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients

The paper identifies an immunodominant B cell response targeting specific HLA residues in transplant recipients, suggesting antigenic topography drives antibody-mediated rejection.

SiHDA9 interacts with SiHAT3.1 and SiHDA19 to repress dehydration responses through H3K9 deacetylation in foxtail millet

The paper identifies SiHDA9's role in repressing drought responses by deacetylating H3K9 on target genes in foxtail millet through interaction with SiHAT3.1 and SiHDA19.

Deciphering drug response and phenotypic heterogeneity of cancer cells using gene ensembles of regulatory units defined by chromatin domains

The paper analyzes the relationship between TAD activity and drug response in cancer cells and patients, finding stronger correlations with TADs than individual genes.