Primate heart regeneration via migration and fibroblast repulsion by human heart progenitors
C. Schneider, K. S. Foo, M. T. De Angelis, G. Santamaria, F. Reiter, T. Dorn, A. Bähr, Y. L. Tsoi, P. Hoppmann, I. My, A. Meier, V. Jurisch, N. Hornaschewitz, S. Schwarz, K. Lu, , K.-L. Laugwitz
This study shows human heart progenitors can regenerate primate hearts by migrating to injury sites, repelling fibroblasts, and replacing damaged tissue through CXCL12/CXCR4 and SLIT2/ROBO1 signaling.
bioRxiv · Jul 3, 2020 · PreprintCell Biology