C. Schneider

Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation

The paper shows tuft cell IL-17RB limits IL-25 bioavailability, preventing excessive ILC2 activation and causing hypoproliferation under certain conditions.

Cell-state plasticity drives heterogeneity in Group 3/4 medulloblastoma

This study identifies cell-state plasticity as a driver of heterogeneity in Group 3/4 medulloblastomas, showing that transcription factor perturbation can redirect tumor cells along different differentiation trajectories.

Atypical Protein Kinase C Promotes its own Asymmetric Localisation by Phosphorylating Cdc42 in Polarising Cells

This paper shows that aPKC phosphorylates Cdc42 to regulate its own asymmetric localization and cell polarity in C. elegans zygotes.

CSF1R-dependent macrophages in the salivary gland are essential for epithelial regeneration following radiation-induced injury

This study identifies CSF1R-dependent macrophages as critical for epithelial regeneration after radiation-induced salivary gland injury.

The 5-LOX/COX-2 cross-over metabolite, hemiketal E2, enhances VEGFR2 activation and promotes angiogenesis

This study identifies HKE2, a cross-over metabolite of 5-LOX and COX-2, as a pro-angiogenic agent that activates VEGFR2 and promotes angiogenesis in vitro and in vivo.

Reconstructing the ancestral vertebrate brain using a lamprey neural cell type atlas

This study reconstructs the ancestral vertebrate brain by comparing a lamprey neural cell type atlas with data from jawed vertebrates, identifying shared features and evolutionary novelties.

Global monitoring of soil animal communities using a common methodology

The paper introduces a global collaborative network to standardize soil animal community monitoring and food web analysis across diverse ecosystems.

Cellular development and evolution of the mammalian cerebellum

This study uses single-nucleus RNA-sequencing to compare cerebellar development across human, mouse, and opossum, revealing conserved and species-specific gene expression patterns.

The molecular evolution of spermatogenesis across mammals

This study analyzes single-nucleus transcriptomes from testes across eleven mammalian species to uncover molecular evolution patterns in spermatogenesis.

Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells

This study identifies intrinsic and acquired resistance mechanisms to CNDAC and related nucleoside analogues in AML cells, showing distinct roles of SAMHD1 and DCK.

Long-term culture of fetal monocyte precursors in vitro allowing the generation of bona fide alveolar macrophages in vivo

This study demonstrates the in vitro generation of alveolar macrophage-like cells from fetal liver monocytes using GM-CSF, which can engraft in vivo and protect against respiratory infections.

How much pollen do solitary bee larvae consume? Or establishing realistic exposure estimates of solitary bee larvae via pollen for the use in risk assessment

The paper develops scaling models to estimate pollen consumption by solitary bee larvae using adult body weight, supporting their validity with literature and experimental data to improve risk assessment.

Pre-existing chromatin accessibility and gene expression differences among naïve CD4+ T cells influence effector potential

The paper shows pre-existing transcriptional and chromatin differences in naive CD4+ T cells influence their effector lineage potential.

Epitope profiling of coronavirus-binding antibodies using computational structural modelling

This paper introduces a computational method to profile epitopes of coronavirus-binding antibodies using structural modeling, revealing that sequence-dissimilar antibodies can bind the same epitope.

Alveolar macrophages strictly rely on GM-CSF from alveolar epithelial type 2 cells before and after birth

This study identifies that alveolar epithelial type 2 cells provide essential GM-CSF for alveolar macrophage development and maintenance before and after birth.

From adverse to beneficial - contrasting dietary effects of freshwater mixotrophs on zooplankton

This study contrasts the dietary effects of freshwater mixotrophs on zooplankton, finding that species-specific toxicity and environmental factors influence survival outcomes.

Intermittent Bulk Release of Human Cytomegalovirus

This study identifies a novel HCMV egress pathway involving intermittent bulk release of virions from multiviral bodies.

Saccharomyces cerevisiae Ecm2 Modulates the Catalytic Steps of pre-mRNA Splicing

This study investigates the role of Ecm2 in yeast splicing, showing it modulates catalytic steps and facilitates splice site usage.

Primate heart regeneration via migration and fibroblast repulsion by human heart progenitors

This study shows human heart progenitors can regenerate primate hearts by migrating to injury sites, repelling fibroblasts, and replacing damaged tissue through CXCL12/CXCR4 and SLIT2/ROBO1 signaling.

Adhesion-mediated mechanosignaling forces mitohormesis

The paper shows that adhesion-mediated mechanosignaling activates a mitochondrial stress response through SLC9A1 and HSF1, altering mitochondrial function in aging and cancer.

SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine

This study identifies SAMHD1 as a key regulator of nelarabine response in acute lymphoblastic leukaemias, showing lineage-specific differences in SAMHD1 expression and methylation.

Human cytomegalovirus nuclear capsid motility is non-directed and independent of nuclear actin bundles

This study investigates whether HCMV-induced nuclear actin bundles mediate capsid transport, finding no evidence of directed motility or active transport along nuclear F-actin.

The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1

This study investigates how cancer drugs interact with SAMHD1's catalytic and allosteric sites, finding that drug efficacy is affected by SAMHD1 activity and that only cladribine-TP induces the active tetramer.