A. Moretti

Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis.

This study identifies 14-3-3 binding sites in BR signaling components and shows their role as negative regulators in Arabidopsis.

Gene Therapy for Cardiomyopathy associated with Duchenne Muscular Dystrophy in a Pig Model

This study shows that AAV1.SERCA2a gene therapy improves heart function and reduces arrhythmia in a pig model of Duchenne muscular dystrophy.

Increased pulmonary monocyte infiltration and attenuated phagocytosis defines perinatal dysfunction of innate immunity in Cystic Fibrosis

The paper identifies increased monocyte infiltration and reduced phagocytosis in CF lungs at birth, suggesting innate immune dysfunction and the need for early treatment.

Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools

This study shows that modulating retinoic acid signaling in human pluripotent stem cells generates heart field-specific progenitors, including a novel juxta-cardiac field, and identifies transcriptional dysregulation in a patient with hypoplastic left heart syndrome.

Use of hiPSC-derived cardiomyocytes to rule out proarrhythmic effects of drugs: the case of hydroxychloroquine in COVID-19

This study uses hiPSC-derived cardiomyocytes to assess the proarrhythmic effects of hydroxychloroquine in healthy and LQTS patients, showing differential susceptibility to drug-induced arrhythmias.

Primate heart regeneration via migration and fibroblast repulsion by human heart progenitors

This study shows human heart progenitors can regenerate primate hearts by migrating to injury sites, repelling fibroblasts, and replacing damaged tissue through CXCL12/CXCR4 and SLIT2/ROBO1 signaling.

Molecular mechanism for the recognition of sequence-divergent CIF peptides by the plant receptor kinases GSO1/SGN3 and GSO2.

This paper identifies the molecular mechanism by which plant receptor kinases GSO1/SGN3 and GSO2 recognize sequence-divergent CIF peptides through structural and biochemical analyses.

Mechanistic analysis of the SERK3 elongated allele defines a role for BIR ectodomains in brassinosteroid signaling

The paper investigates the role of the SERK3 elongated allele in brassinosteroid signaling, finding that it disrupts BIR ectodomain interactions with co-receptors rather than enhancing BRI1 binding.