Extracellular Granzyme B Promotes Melanocytorrhagy, Melanocyte Senescence and Aberrant Epidermal Differentiation in Vitiligo and Is Therapeutically Targetable
D. Siwei, Lingye Jin, Beáta Szilvia Bolla, Hiroto Kuwabiraki, Y. Kuroda, Fei Yang, Lingli Yang, Ichiro Katayama, Daisuke Tsuruta, David James Granville, Sho Hiroyasu
This study shows extracellular Granzyme B contributes to vitiligo by causing melanocyte detachment, senescence, and abnormal epidermal differentiation, and identifies it as a therapeutic target.
bioRxiv · Sep 24, 2026 · PreprintImmunology