Molecular basis for inhibition of adhesin-mediated bacterial-host interactions through a novel peptide-binding domain
S. Guo, H. Zahiri, C. Stevens, D. Spaanderman, L.-G. Milroy, C. Ottmann, L. Brunsveld, I. Voets, P. Davies
The paper identifies a peptide-binding domain in a bacterial adhesion protein and develops ligands that inhibit its function, suggesting potential for disrupting harmful bacterial-host interactions.
bioRxiv · Nov 18, 2020Microbiology