S. Guo

KLHDC7B as a Potential Therapeutic Target in Systemic Lupus Erythematosus: Insights from Bulk and Single-Cell RNA-Seq and Spatial Transcriptomics of Epidermal Keratinocytes

PCM1 conveys centrosome asymmetry to polarized endosome dynamics in regulating daughter cell fate

This study shows that Pcm1 regulates asymmetric endosome dynamics and RGP fate by coordinating Rab5b and Rab11a endosome markers and Par-3/dynein complexes in zebrafish and human brain organoids.

SASH1 impairs melanin synthesis and metastasis by down-regulating the TGF-β signaling pathway

This study shows SASH1 reduces melanin synthesis and metastasis by suppressing TGF-β1 signaling through regulation of THBS1 in melanocytes.

Temperature-Dependent Fold-Switching Mechanism of the Circadian Clock Protein KaiB

This study investigates how temperature affects the fold-switching mechanism of KaiB, a circadian clock protein, showing that proline isomerization is a rate-limiting step.

VGLL2 and TEAD1 fusion proteins drive YAP/TAZ-independent tumorigenesis by engaging p300

This study identifies VGLL2 and TEAD1 fusion proteins as YAP/TAZ-independent drivers of tumorigenesis by recruiting p300 for epigenetic regulation.

Microbial community assembly during aging of food waste-derived hydrochar: key bacterial guilds mediate nutrient dynamics

This study investigates how adding straw and microbes accelerates hydrochar aging by identifying key bacterial guilds involved in nutrient cycling.

Structural insights into sphingosine 1-phosphate receptor 4 activation

The paper determines the cryo-EM structure of activated S1PR4, revealing mechanisms of ligand recognition and Gi coupling to aid in developing safer S1PR4 agonists.

ATG6 interacting with NPR1 increases Arabidopsis thaliana resistance to Pst DC3000/avrRps4 by increasing its nuclear accumulation and stability

This study shows ATG6 interacts with NPR1, enhancing its nuclear accumulation and stability, which boosts Arabidopsis resistance to Pst DC3000/avrRps4.

CD81+ senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis

This study identifies CD81+ senescent fibroblasts as key drivers of inflammation in periodontitis through the C3/C3aR1 axis and shows that senolytics and metformin can reduce inflammation and bone loss.

Chromosome segment scanning for gain- or loss-of-function screening (CHASING) and its application in metabolic engineering

The paper introduces CHASING, a method for gain- or loss-of-function screening using chromosome-segment deletions, and applies it to identify metabolic engineering targets in B. subtilis.

IL-1beta-induced epithelial cell and fibroblast transdifferentiation fuels neutrophil recruitment in chronic rhinosinusitis with nasal polyps

This study identifies IL-1beta-induced cell subsets that promote neutrophil recruitment in CRSwNP and shows IL-1beta inhibition reduces inflammation.

Increased interaction between connexin43 and microtubules is critical for glioblastoma stem-like cell maintenance and tumorigenicity.

This study identifies a novel peptide, JM2, that disrupts Cx43-microtubule interaction in GBM stem-like cells, reducing their survival and tumorigenicity.

Orphan nuclear receptor NR2E3 and its small-molecule agonist induce cancer cell apoptosis through regulating p53, IFNα and MYC pathways

This study shows NR2E3 activates p53 and induces apoptosis in cancer cells, with its agonist 11a synergizing with Romidepsin to suppress cervical cancer through multiple molecular mechanisms.

The 3D ultrastructural morphology of a marine ammonia-oxidizing archaeon

This study uses cryo-ET and STEM-EDS to reveal the ultrastructural morphology and elemental composition of Nitrosopumilus maritimus SCM1, identifying two types of storage granules.

Structure basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor

This study determines the cryo-EM structure of QRFPR bound to 26RFa, revealing the recognition mechanism and aiding drug design for obesity and diabetes.

A peptide-centric local stability assay to unveil protein targets of diverse ligands

This paper introduces PELSA, a peptide-centric local stability assay that identifies ligand-binding regions across the proteome with high sensitivity and without ligand modification.

Repression of mRNA translation initiation by GIGYF1 via blocking the eIF3-eIF4G1 interaction

This study identifies GIGYF1 as a repressor of mRNA translation by disrupting the eIF3-eIF4G1 interaction, enhancing host immune response by derepressing Ifnb1 mRNA.

Role of C2-domain protein CAR1 in the plasma membrane ABA signaling response

This study investigates CAR1's role in PM-associated ABA signaling, showing ABA affects CAR1 dynamics and its ability to recruit HAB1 and SnRK2.2 to the PM.

Nifuroxazide Suppresses PD-L1 Expression and Enhances the Efficacy of Radiotherapy in Hepatocellular Carcinoma

This study shows nifuroxazide enhances radiotherapy in HCC by reducing PD-L1 expression and improving tumor response.

Ice nucleation proteins self-assemble into large fibres to trigger freezing at near 0 ℃

The paper shows ice nucleation proteins self-assemble into fibres that trigger freezing near 0 ℃ by forming multimers essential for frost formation.

Collective dynamics of formin and microtubule and its crosstalk mediated by FHDC1

This study investigates the collective dynamics of formin and microtubule networks, revealing FHDC1's role in regulating actin wave nucleation and its crosstalk with microtubules.

De novo progesterone synthesis in plants

This study identifies the complete pathway for progesterone biosynthesis in Marsdenia tenacissima, involving specific P450scc and MtHSD5 enzymes, enabling sustainable steroid hormone drug synthesis.

Visualization of syntrophic benzene-fermenting Desulfobacterota ORM2 in a methanogenic enrichment culture using fluorescence in situ hybridization

This study visualizes Desulfobacterota ORM2 cells using FISH, revealing their spatial organization and potential role in growth lag phases in a methanogenic culture.

Morphomechanic tuning of ERK by actin-TFII-IΔ regulates cell identity

The paper shows that actin-TFII-IΔ modulates ERK activity through cell height to direct cell fate during reprogramming.

The first complete mitochondrial genome of Sphaeniscus atilius (Walker, 1849) (Diptera: Tephritidae) and implications for the phylogenetic relationships of Tephritidae

This study characterizes the first complete mitochondrial genome of Sphaeniscus atilius and presents phylogenetic insights for Tephritidae family relationships.

Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

This study shows that angiogenesis inhibitors enhance the effectiveness of metabolic therapies in gliomas by inducing anaplerotic nutrient stress.

Step-wise mechanical unfolding and dissociation of the GAIN domains of ADGRG1/GPR56, ADGRL1/Latrophilin-1 and ADGRB3/BAI3: insights into the mechanical activation hypothesis of adhesion G protein-coupled receptors

This study examines how mechanical forces affect the GAIN domains of three aGPCRs, showing force-induced destabilization and detachment, supporting the mechanical activation hypothesis.

Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin-beta receptor signaling

The paper shows that leukemic cells activate LTβR signaling in mesenchymal stem cells, suppressing IL7 production and lymphopoiesis while promoting leukemia growth.

A reductase in the lipid metabolism at cross roads between cuticular wax production and jasmonic acid-mediated defenses in maize

This study identifies ZmGL8 as a key gene regulating the balance between cuticular wax production and jasmonic acid-mediated defenses in maize, showing its role in modulating plant defense responses.

Serum response factor reduces gene expression noise and confers cell state stability

This study shows that Srf reduces gene expression noise and stabilizes cell state in mouse pluripotent stem cells by limiting developmental heterogeneity.