Functional and LC-MS/MS analysis of in vitro transcribed mRNAs carrying phosphorothioate or boranophosphate moieties reveal polyA tail modifications that prevent deadenylation without compromising protein expression
D. Strzelecka, M. Smietanski, P. Sikorski, M. Warminski, J. Kowalska, J. Jemielity
This study examines how phosphorothioate and boranophosphate modifications in mRNA polyA tails affect deadenylation resistance and protein expression.
bioRxiv · Jul 2, 2020 · PreprintBiochemistry