Author

J. Jemielity

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Assay:bulk RNA-seq· 2 Approach:deep learning· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. Kowalska· 5 shared M. Warminski· 5 shared D. Nowis· 3 shared P. J. Sikorski· 3 shared J. Golab· 2 shared M. Smietanski· 2 shared T. Spiewla· 2 shared A. Brouze· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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5 shared papersBiochemistry

J. Kowalska

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Trinucleotide mRNA cap analog N6-benzylated at the site of posttranscriptional m6Am mark facilitates mRNA purification and confers superior translational properties in vitro and in vivo

M. Warminski, E. Trepkowska, M. Smietanski, P. J. Sikorski, M. R. Baranowski, M. Bednarczyk, H. Kedzierska, B. Majewski, A. Mamot, D. Papiernik, A. Popielec, R. Serwa, B. A. Shimanski, P. Sklepkiewicz, M. Sklucka, , J. Kowalska

This paper introduces a modified mRNA cap analog, AvantCap, which improves mRNA purification and translational efficiency in vitro and in vivo.

bioRxiv · Nov 10, 2023 · PreprintBiochemistry

SARS-CoV-2 mRNA vaccine is re-adenylated in vivo, enhancing antigen production and immune response

P. S. Krawczyk, O. Gewartowska, M. Mazur, W. Orzel, K. Matylla-Kulinska, S. Jelen, P. Turowski, T. Spiewla, B. Tarkowski, A. Tudek, A. Brouze, A. Wesolowska, D. Nowis, J. Golab, J. Kowalska, , S. Mroczek

This study shows that SARS-CoV-2 mRNA vaccines are re-adenylated in vivo, increasing antigen production and immune response in macrophages.

bioRxiv · Dec 1, 2022 · PreprintImmunology

2'-O -methylation of the second transcribed nucleotide within mRNA 5' cap impacts protein production level in a cell specific manner and contributes to RNA immune evasion

K. Drazkowska, N. Baran, M. Warminski, R. Tomecki, A. Depaix, D. Cysewski, R. Kasprzyk, J. Kowalska, J. Jemielity, P. J. Sikorski

This study shows that 2'-O-methylation of the second transcribed nucleotide in mRNA 5' cap affects protein production levels and contributes to RNA immune evasion in a cell-specific manner.

bioRxiv · Feb 3, 2022Biochemistry

Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis

J. K. Peters, R. W. Tibble, M. Warminski, J. Jemielity, J. D. Gross

The paper determines the structure of the poxvirus decapping enzyme D9, revealing its mechanism for recognizing and catalyzing the removal of the 5' cap from mRNA.

bioRxiv · Oct 4, 2021Biophysics

Functional and LC-MS/MS analysis of in vitro transcribed mRNAs carrying phosphorothioate or boranophosphate moieties reveal polyA tail modifications that prevent deadenylation without compromising protein expression

D. Strzelecka, M. Smietanski, P. Sikorski, M. Warminski, J. Kowalska, J. Jemielity

This study examines how phosphorothioate and boranophosphate modifications in mRNA polyA tails affect deadenylation resistance and protein expression.

bioRxiv · Jul 2, 2020 · PreprintBiochemistry

The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5' cap modulates protein expression in living cells

P. J. Sikorski, M. Warminski, D. Kubacka, T. Ratajczak, D. Nowis, J. Kowalska, J. Jemielity

bioRxiv · Nov 25, 2019Biochemistry