Recognition of N6-methyladenosine by the YTHDC1 YTH domain studied by molecular dynamics and NMR spectroscopy: The role of hydration
M. Krepl, F. Damberger, C. von Schroetter, D. Theler, P. Pokorna, F. Allain, J. Sponer
This study investigates how YTHDC1 recognizes m6A through molecular dynamics, NMR, and ITC, showing that hydration and water networks are critical for m6A selectivity.
bioRxiv · Feb 8, 2021Biophysics