A ganglioside-based senescence-associated immune checkpoint
C. Iltis, L. Seguin, L. Cervera, L. Duret, T. Hamidouch, S. Kunz, O. Croce, C. Delannoy, Y. Guerardel, F. Allain, L. Moudombi, P. Hofman, E. Cosson, J. Guglielmi, T. Pourcher, , J. Cherfils-Vicini
This paper identifies GD3 as a senescence-associated immune checkpoint that suppresses NK cell-mediated clearance of senescent cells, showing that targeting GD3 can enhance anti-fibrotic effects in a mouse model.
bioRxiv · Apr 23, 2021 · PreprintImmunology