New Structural Insights into the Function of the Catalytically Active Human Taspase1
N. Nagaratnam, S. Delker, R. Jernigan, T. E. Edwards, J. Snider, D. Thifault, D. Williams, B. L. Nannenga, M. Stofega, L. Sambucetti, J. Hsieh, A. J. Flint, P. Fromme, J. M. Martin-Garcia
This study determines the crystal structure of catalytically active human Taspase1 and identifies a long helical domain essential for its enzymatic activity, suggesting it as a potential target for anticancer therapeutics.
bioRxiv · Nov 26, 2020Biochemistry