D. Williams

Development of quantitative high-throughput screening assays to identify, validate, and optimize small-molecule stabilizers of misfolded β-glucocerebrosidase with therapeutic potential for Gaucher disease and Parkinson's disease

This paper develops high-throughput assays to identify and optimize small-molecule stabilizers of misfolded β-glucocerebrosidase, showing NCGC326 reverses pathological accumulation and synergizes with proteostasis regulators.

Structure and dynamics of the autoantigen GAD65 in complex with the human autoimmune polyendocrine syndrome type 2-associated autoantibody b96.11

This study characterizes the structure and dynamics of GAD65 and its interaction with autoantibody b96.11, revealing how intrinsic conformational flexibility drives autoantigenicity.

Raspberry plant stress detection using hyperspectral imaging

This study uses hyperspectral imaging to detect below ground stress in raspberry plants by analyzing spectral reflectance differences across genotypes and stress treatments.

The QseB response regulator imparts tolerance to positively charged antibiotics by controlling metabolism and minor changes to LPS

This paper shows QseB enhances polymyxin B tolerance in UPEC by modifying LPS and regulating glutamate metabolism, revealing a new mechanism of antibiotic resistance.

Deciphering the non-coding code of pathogenicity and sexual differentiation in the human malaria parasite.

This study identifies and characterizes long non-coding RNAs (lncRNAs) in Plasmodium falciparum, revealing their role in gene regulation, pathogenicity, and sexual differentiation.

Structure of the Inmazeb cocktail and resistance to escape against Ebola virus

The paper presents the cryoEM structure of the Inmazeb cocktail in complex with Ebola virus glycoprotein, showing how the combination prevents escape mutations better than monotherapy.

Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation

This study identifies Apolipoprotein E's role in Dectin-1-dependent development of monocyte-derived alveolar macrophages during pulmonary β-glucan-induced inflammation.

Assessment of endocytic traffic and Ocrl function in the developing zebrafish neuroepithelium

The paper describes live imaging assays to study endocytosis in zebrafish neuroepithelium and identifies a role for the OCRL protein in this process.

Whole genome sequencing suggests that non-pathogenicity on banana (NPB) is the ancestral state of the Ralstonia solanacearum IIB-4 lineage.

Stable Flow-induced Expression of KLK10 Inhibits Endothelial Inflammation and Atherosclerosis

This study identifies KLK10 as a flow-sensitive endothelial protein that inhibits inflammation and atherosclerosis through a PAR1/2-dependent mechanism involving HTRA1 regulation.

The structure of the Physcomitrium Patens Photosystem I Reveals a Unique Lhca2 Paralogue replacing Lhca4

The paper presents the Cryo-EM structure of the Physcomitrium patens PSI-LHCI supercomplex, revealing a unique Lhca2 paralogue replacing Lhca4 and adaptations to low light environments.

Statistics of antibody binding to the spike protein explain the dependence of COVID 19 infection risk on antibody concentration and affinity

The paper explains how antibody concentration and affinity affect COVID-19 infection risk through statistical binding models of antibodies to the spike protein.

NLRP3 activation in response to disrupted endocytic traffic

This study shows NLRP3 detects disrupted endosome trafficking, leading to inflammasome activation and cytokine release in macrophages.

The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation

This study presents cryo-EM structures of Ycf1 showing how phosphorylation of the regulatory domain modulates its interaction with NBD1 and affects ATPase activity.

The component parts of bacteriophage virions accurately defined by a machine-learning approach built on evolutionary features.

This paper develops a machine learning tool called STEP3 to accurately define bacteriophage virion components using evolutionary features, validated with mass spectrometry.

New Structural Insights into the Function of the Catalytically Active Human Taspase1

This study determines the crystal structure of catalytically active human Taspase1 and identifies a long helical domain essential for its enzymatic activity, suggesting it as a potential target for anticancer therapeutics.

Examination of a first-in-class bis-dialkylnorspermidine-terphenyl antibiotic in topical formulation against mono and polymicrobial biofilms

This study evaluates a new antibiotic, CZ-01179, against biofilms using in vitro methods and finds it more effective than current standards in eradicating mature biofilms.

Improving drug safety predictions by reducing poor analytical practices

The paper identifies poor analytical practices in drug safety prediction models and proposes solutions to improve their reliability.

A Meta-analysis of the known Global Distribution and Host Range of the Ralstonia Species Complex

The paper updates a database documenting the global distribution and host range of Ralstonia species, including new reports on several lineages.

Determining organ weight toxicity with Bayesian causal models: Improving on the analysis of relative organ weights

The paper proposes using Bayesian causal models to improve the analysis of organ weight toxicity by addressing limitations in traditional methods like relative organ weight and ANCOVA.

The physical form of microbial ligands bypasses the need for dendritic cell migration to stimulate adaptive immunity

This study shows that soluble fungal polysaccharides are immunosilent in peripheral tissues but become potent immunogens in draining lymph nodes without requiring dendritic cell migration.

JAK Inhibitors Suppress Colon Cancer Cachexia-Associated Anorexia and Adipose Wasting in Mice

This study shows JAK inhibitors reduce cachexia-associated anorexia and adipose wasting in colon cancer models by blocking cytokine-induced pathways.

Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells

This study shows that hepatocyte-derived microRNA, particularly miR-122, is transferred to kidney tubular cells and regulates CYP2E1 expression, influencing drug toxicity.

GSMN-ML- a genome scale metabolic network reconstruction of the obligate human pathogen Mycobacterium leprae

This paper reconstructs a genome-scale metabolic network for Mycobacterium leprae to study its metabolism and identify potential drug targets.

Plasmodium Kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission

This study identifies Plasmodium Kinesin-8X as essential for endomitotic division during oocyst development and parasite transmission.

Liver-Chip: Reproducing Human and Cross-Species Toxicities

The paper designs Liver-Chips for rat, dog, and human to replicate species-specific liver toxicities and predict human relevance.

Multi-plane Imaging of Neural Activity From the Mammalian Brain Using a Fast-switching Liquid Crystal Spatial Light Modulator

The paper introduces a new two-photon microscope using a liquid crystal spatial light modulator to record neural activity in awake mice, finding heterogeneous responses in excitatory neurons across cortical layers.

Growth substrate may influence biofilm susceptibility to antibiotics

This study compares antibiotic susceptibility of biofilms grown on collagen versus polycarbonate substrates, finding that collagen-grown biofilms are more resistant in 13/18 cases.

Engineering of a Polydisperse Small Heat-Shock Protein Reveals Conserved Motifs of Oligomer Plasticity

This study engineers a polydisperse small heat-shock protein to reveal conserved motifs of oligomer plasticity through structural and functional analysis.