Inflammatory Recruitment of Healthy Hematopoietic Stem and Progenitor Cells in the Acute Myeloid Leukemia Niche
D.-W. Chen, J.-M. Fan, J. M. Schrey, D. V. Mitchell, S. K. Jung, S. N. Hurwitz, E. B. Perez, M. Muraro, M. Carroll, D. M. Taylor, P. Kurre
This study shows that healthy hematopoietic stem and progenitor cells (HSPCs) adopt inflammatory gene expression programs in the AML niche, driven by AML-derived extracellular vesicles.
bioRxiv · Nov 22, 2023Cancer Biology