Structural basis of GAIN domain autoproteolysis and cleavage-resistance in the adhesion G-protein coupled receptors
F. Pohl, F. Seufert, Y. K. Chung, D. Volke, R. Hoffmann, T. Schoneberg, T. Langenhan, P. W. Hildebrand, N. Strater
This study identifies structural determinants that confer resistance to autoproteolysis in adhesion GPCRs despite the presence of a canonical GPS motif.
bioRxiv · Mar 12, 2023Biochemistry