Author

T. Langenhan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Organism:Drosophila· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Fu· 1 shared C. Hu· 1 shared D. Sachidanandan· 1 shared D. Volke· 1 shared F. Pohl· 1 shared F. Seufert· 1 shared G. Song· 1 shared H. Rittner· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperBiophysics

C. Fu

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3 papers

Recent·Most cited

Step-wise mechanical unfolding and dissociation of the GAIN domains of ADGRG1/GPR56, ADGRL1/Latrophilin-1 and ADGRB3/BAI3: insights into the mechanical activation hypothesis of adhesion G protein-coupled receptors

C. Fu, W. Huang, Q. Tang, M. Niu, S. Guo, T. Langenhan, G. Song, J. Yan

This study examines how mechanical forces affect the GAIN domains of three aGPCRs, showing force-induced destabilization and detachment, supporting the mechanical activation hypothesis.

bioRxiv · Mar 14, 2023 · PreprintBiophysics

Structural basis of GAIN domain autoproteolysis and cleavage-resistance in the adhesion G-protein coupled receptors

F. Pohl, F. Seufert, Y. K. Chung, D. Volke, R. Hoffmann, T. Schoneberg, T. Langenhan, P. W. Hildebrand, N. Strater

This study identifies structural determinants that confer resistance to autoproteolysis in adhesion GPCRs despite the presence of a canonical GPS motif.

bioRxiv · Mar 12, 2023Biochemistry

Antinociceptive modulation by the adhesion-GPCR CIRL promotes mechanosensory signal discrimination

S. Dannhäuser, T. J. Lux, C. Hu, M. Selcho, J. Tsung-Chieh Chen, N. Ehmann, D. Sachidanandan, M. Pawlak, T. Langenhan, P. Soba, H. Rittner, R. J. Kittel

This study shows that CIRL modulates mechanosensory signals differently in low-threshold mechanoreceptors and high-threshold nociceptors, aiding in signal discrimination.

bioRxiv · Feb 24, 2020Physiology