Author

R. Hoffmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Paleontology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Approach:Bayesian inference· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

A. Immenhauser· 1 shared A. Pohle· 1 shared C. Gulliver· 1 shared C. Martins· 1 shared D. M. Rassl· 1 shared D. Macias· 1 shared D. Munoz-Espin· 1 shared D. Veroutis· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperPaleontology

A. Immenhauser

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural basis of GAIN domain autoproteolysis and cleavage-resistance in the adhesion G-protein coupled receptors

F. Pohl, F. Seufert, Y. K. Chung, D. Volke, R. Hoffmann, T. Schoneberg, T. Langenhan, P. W. Hildebrand, N. Strater

This study identifies structural determinants that confer resistance to autoproteolysis in adhesion GPCRs despite the presence of a canonical GPS motif.

bioRxiv · Mar 12, 2023Biochemistry

Bayesian inference reveals a complex evolutionary history of belemnites

K. Stevens, A. Pohle, R. Hoffmann, A. Immenhauser

This study uses Bayesian inference to reconstruct the evolutionary history of belemnites, revealing new phylogenetic relationships and challenging previous classifications.

bioRxiv · Aug 22, 2022 · PreprintPaleontology

A tumour-promoting senescent secretome triggered by platinum chemotherapy exploits a targetable TGFβR1/Akt-mTOR axis in lung cancer

E. Gonzalez-Gualda, D. Macias, S. Morsli, E. Martin, H.-L. Ou, M. Denholm, I. Olan, R. Hoffmann, M. Dane, D. Veroutis, G. Medrano, F. Mulero, C. Martins, M. Barbacid, V. Gorgoulis, , D. Munoz-Espin

This study shows platinum chemotherapy induces a senescent secretome in lung cancer that promotes tumor growth via the TGFβR1/Akt-mTOR axis, and targeting this pathway reduces tumor burden.

bioRxiv · Aug 1, 2022 · PreprintCancer Biology

Reduced PDE4D7 expression in prostate cancer correlates with down-regulation of genomic elements within the upstream PDE4D coding region on chromosome 5

C. Gulliver, G. S. Baillie, R. Hoffmann

The paper identifies PDE4D7 expression reduction in prostate cancer and links it to genomic elements in the upstream PDE4D coding region, suggesting potential biomarkers and mechanistic roles in cancer progression.

bioRxiv · Jun 16, 2022 · PreprintCancer Biology