RBM10 loss induces aberrant splicing of cytoskeletal and extracellular matrix mRNAs and promotes metastatic fitness.
G. P. Krishnamoorthy, A. R. Glover, B. R. Untch, N. F. Sigcha-Coello, B. Xu, D. Vukel, Y. Liu, V. Tiedje, K. Berman, P. P. Tamarapu, A. Acuna-Ruiz, M. Saqcena, E. de Stanchina, L. Boucai, R. A. Ghossein, , J. A. Fagin
This study shows that RBM10 loss causes aberrant splicing of cytoskeletal and ECM genes, leading to RAC1 activation and metastatic fitness in thyroid cancer.
bioRxiv · Jul 9, 2024 · PreprintCancer Biology