Single-Cell RNA Sequencing Reveals the Effects of Chemotherapy on Human Pancreatic Adenocarcinoma and its Tumor Microenvironment
G. Werba, D. Weissinger, E. A. Kawaler, E. Zhao, D. Kalfakakou, S. Dhara, G. Oh, X. Jing, N. Beri, L. Khanna, T. Gonda, P. Oberstein, C. Hajdu, C. A. Loomis, A. Heguy, , D. M. Simeone
This study uses single-cell RNA sequencing to analyze how chemotherapy affects PDAC tumor cells and their microenvironment, finding limited transcriptional shifts and reduced TIGIT-mediated immune checkpoint activity.
bioRxiv · May 24, 2022Cancer Biology