Author

A. Heguy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Microbiology· 2 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 8 Approach:experimental assay· 5 Approach:statistical model· 5 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Assay:whole-genome sequencing· 3 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

A. Tsirigos· 3 shared A. Pironti· 2 shared D. Dimartino· 2 shared M. Olivier· 2 shared P. Meyn· 2 shared S. Villar· 2 shared Z. Chen· 2 shared A. Boot· 1 shared

Activity by Year

2017-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

A. Tsirigos

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

MethNet: a robust approach to identify regulatory hubs and their distal targets in cancer

T. Sakellaropoulos, C. Do, G. Jiang, G. Cova, P. Meyn, D. Dimartino, S. Ramaswami, A. Heguy, A. Tsirigos, J. A. Skok

MethNet identifies regulatory hubs and their distal targets in cancer by integrating DNA methylation and gene expression data to uncover cis regulatory elements linked to patient survival.

bioRxiv · Jul 7, 2023 · PreprintCancer Biology

Lupus disease flares are concordant with immune responses to blooms of lipoglycan-expressing Ruminococcus blautia gnavus strains arising from unstable gut microbiota communities

D. F. Azzouz, Z. Chen, P. Izmirly, L. A. Chen, Z. Li, A. Pironti, G. G. Putzel, C. Zhang, A. Heguy, M. Masson, D. Schwudke, D. Fenyo, N. Gisch, J. H. Buyon, A. V. Alekseyenko, G. J. Silverman

bioRxiv · Jun 28, 2022 · PreprintImmunology

Single-Cell RNA Sequencing Reveals the Effects of Chemotherapy on Human Pancreatic Adenocarcinoma and its Tumor Microenvironment

G. Werba, D. Weissinger, E. A. Kawaler, E. Zhao, D. Kalfakakou, S. Dhara, G. Oh, X. Jing, N. Beri, L. Khanna, T. Gonda, P. Oberstein, C. Hajdu, C. A. Loomis, A. Heguy, , D. M. Simeone

This study uses single-cell RNA sequencing to analyze how chemotherapy affects PDAC tumor cells and their microenvironment, finding limited transcriptional shifts and reduced TIGIT-mediated immune checkpoint activity.

bioRxiv · May 24, 2022Cancer Biology

Delta-Omicron recombinant escapes therapeutic antibody neutralization

R. Duerr, H. Zhou, T. Tada, D. Dimartino, C. Marier, P. Zappile, G. Wang, J. Plitnick, S. Griesemer, R. C. Girardin, J. Machowski, S. Bialosuknia, E. Lasek-Nesselquist, S. L. Hong, G. Baele, , A. Heguy

This study identifies a Delta-Omicron recombinant SARS-CoV-2 variant that escapes Sotrovimab neutralization, highlighting the role of recombination in immune escape.

bioRxiv · Apr 6, 2022Microbiology

Little skate genome exposes the gene regulatory mechanisms underlying the evolution of vertebrate locomotion

M. Baek, D. Yoo, C. Lee, J. Park, Y. H. Lee, A. Heguy, J. S. Dasen, H. Kim

The paper generates a high-quality little skate genome and analyzes motor neuron gene regulation across species to identify conserved and divergent mechanisms in vertebrate locomotion evolution.

bioRxiv · Mar 14, 2022 · PreprintEvolutionary Biology

Clostridia isolated from helminth-colonized humans promote hatching of Trichuris muris

S. Sargsian, Z. Chen, S. C. Lee, A. Robertson, J. Sproch, J. C. Devlin, M. Z. Tee, Y. X. Er, R. Copin, A. Heguy, A. Pironti, V. J. Torres, K. V. Ruggles, Y. A. L. Lim, P. Loke, K. Cadwell

The paper isolates and characterizes Clostridia from helminth-colonized humans, showing they promote hatching of Trichuris muris eggs.

bioRxiv · Feb 10, 2022Microbiology

Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer

C. A. Chang, J. Jen, S. Jiang, A. Sayad, A. S. Mer, K. R. Brown, A. Nixon, A. Dhabaria, K. H. Tang, D. Venet, C. Sotiriou, J. Deng, K.-k. Wong, S. Adams, P. Meyn, , B. G. Neel

This study identifies drug-tolerant persisters (DTPs) in HER2+ breast cancer and reveals their origins and vulnerabilities to TKI resistance.

bioRxiv · Aug 28, 2020Cancer Biology

Molecular features of premenopausal breast cancers in Latin American women: pilot results from the PRECAMA study

M. Olivier, L. Bouaoun, S. Villar, A. Robitaille, V. Cahais, A. Heguy, G. Byrnes, F. Le Calvez-Kelm, G. Torres-Mejia, I. Alvarado-Cabrero, F. S. Imani-Razavi, G. Ines Sanchez, R. Jaramillo, C. Porras, A. C. Rodriguez, , S. Rinaldi

The paper characterizes molecular features of premenopausal breast cancers in Latin American women using genomic and immunohistochemical analyses, finding distinct mutational patterns in TP53 and exome-wide signatures compared to other populations.

bioRxiv · Aug 25, 2018Cancer Biology

Genome-Scale Mutational Signatures Of Aflatoxin In Cells, Mice And Human Tumors

M. N. Huang, W. Yu, W. W. Teoh, M. Ardin, A. Jusakul, A. Ng, A. Boot, B. Abedi-Ardekani, S. Villar, S. S. Myint, R. Othman, S. L. Poon, A. Heguy, M. Olivier, M. Hollstein, , S. Rozen

This study identifies AFB1 mutational signatures across multiple systems and shows their prevalence in HCCs from different regions, highlighting aflatoxin's public health impact.

bioRxiv · Apr 26, 2017Cancer Biology