X. Jing

TMEM41B is an endoplasmic reticulum Ca2+ release channel maintaining T cell metabolic quiescence and responsiveness

This study identifies TMEM41B as an ER Ca2+ release channel that maintains T cell metabolic quiescence and responsiveness by regulating signaling pathways and receptor expression.

Comparison of chronic aerosol inhalation with combustible cigarette and e-cigarette on the psychiatric behaviors and neuroimmune profile in mice

This study compares the effects of combustible cigarette and e-cigarette aerosol inhalation on psychiatric behaviors and neuroimmune profiles in mice, finding greater anxiety in combustible cigarette exposure.

Phylogeny-metabolism dual-directed single-cell genomics for dissecting and mining ecosystem function

This paper introduces FISH-scRACS-Seq, a method to identify and sequence single cells with specific metabolic functions, revealing a new cyclohexane-degrading enzyme system in marine bacteria.

Warming and altered precipitation independently and interactively suppress alpine soil microbial growth in a decadal-long experiment

This study shows that warming and altered precipitation independently and together reduce alpine soil microbial growth by 40-90%, with some taxa showing increased growth under specific climate conditions.

Massive expansion of the pig gut virome based on global metagenomic mining

This study establishes the Pig Virome Database (PVD) by mining global metagenomic data, revealing extensive viral diversity and functional potential in the pig gut.

A cataract-causing Y204X mutation of CRYβB1 promotes C-terminal degradation and higher-order oligomerization

This study identifies a cataract-causing mutation in CRYβB1 that leads to C-terminal truncation, increased proteolysis, and higher-order oligomerization, contributing to lens opacity.

Soil depth governs microbial community assembly and enzymatic activity in extreme environments

The paper examines how soil depth influences microbial community structure and enzymatic activity in extreme desert environments, finding that depth-related environmental heterogeneity drives these patterns.

Single-Cell RNA Sequencing Reveals the Effects of Chemotherapy on Human Pancreatic Adenocarcinoma and its Tumor Microenvironment

This study uses single-cell RNA sequencing to analyze how chemotherapy affects PDAC tumor cells and their microenvironment, finding limited transcriptional shifts and reduced TIGIT-mediated immune checkpoint activity.

Exosomal miR-769-5p confers cisplatin resistance and tumorigenesis in gastric cancer

This study identifies exosomal miR-769-5p as a mediator of cisplatin resistance in gastric cancer by targeting CASP9 and promoting apoptosis evasion.

A bacterial genome and culture collection of gut microbial in weanling piglet

The paper establishes a bacterial genome and culture collection of the piglet gut microbiome, revealing new species and functional insights.

Development of next-generation sequencing-based sterility test

This study develops a next-generation sequencing-based sterility test (NGSST) that reduces detection time to 48 hours and improves accuracy for biological products.

Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of Covid-19 death

The paper presents autopsies of Covid-19 patients showing pulmonary stromal expansion and intra-alveolar coagulation as primary causes of death, with virus replication in pneumocytes and macrophages.