Dan Xia

Decoding hidden goal-directed navigational states and their neuronal representations using a novel labyrinth paradigm and probabilistic modeling framework

The paper introduces a labyrinth paradigm and probabilistic modeling framework to study hidden navigational states in mice, revealing impaired states in an Alzheimer's model and linking them to gamma oscillations in the PPC.

Anti-Aβ immunotherapy-mediated amyloid clearance attenuates microglial activation without inducing exhaustion at residual plaques

This study shows that long-term anti-Aβ treatment reduces amyloid plaques and microglial activation but leaves residual plaques with persistent immune activity.

Gating of Memory to Behavior by the Locus Coeruleus

This study investigates how retrieved memories direct behavior by showing how transient and sustained neurons in the dmPFC interact with the locus coeruleus to modulate freezing responses to conditioned threats.

Prominent contributions of selective neuronal subtypes to pediatric drug-resistant focal dysplasia

The paper identifies specific neuronal subtypes in pediatric FCD that show significant transcriptomic alterations linked to drug-resistant epilepsy and suggests potential therapeutic targets.

Fibrillar Aβ causes profound microglial metabolic perturbations in a novel APP knock-in mouse model

This paper characterizes microglial metabolic changes in an APP knock-in mouse model of AD, finding lipid dysregulation and immunometabolic perturbations linked to fibrillar Aβ.