Author

Anna Berghofer

German Center for Neurodegenerative Diseases

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

Christian HaassiD· 2 shared Michael WillemiD· 2 shared Stefan F. LichtenthaleriD· 2 shared Stephan A. MülleriD· 2 shared Alessio Vittorio ColomboiD· 1 shared Amelie L. Englert· 1 shared Anke Piechotta· 1 shared Arthur LiesziD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersNeuroscience

Christian HaassORCID

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2 papers

Recent·Most cited

Anti-Aβ immunotherapy-mediated amyloid clearance attenuates microglial activation without inducing exhaustion at residual plaques

Lis de Weerd, Selina Hummel, Stephan A. Müller, Iñaki Paris, Thomas Sandmann, Marie Eichholtz, Robin Gröger, Amelie L. Englert, Stephan Wagner, Connie Ha, Sonnet S. Davis, Valerie Warkins, Dan Xia, Brigitte Nuscher, Anna Berghofer, , Christian Haass

This study shows that long-term anti-Aβ treatment reduces amyloid plaques and microglial activation but leaves residual plaques with persistent immune activity.

bioRxiv · Apr 10, 2025 · PreprintNeuroscience

Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models

Laura Sebastián Monasor, Stephan A. Müller, Alessio Vittorio Colombo, Gaye Tanriöver, Jasmin König, Stefan Roth, Arthur Liesz, Anna Berghofer, Anke Piechotta, Matthias Prestel, Takashi Saito, Takaomi C. Saido, Jochen Wolfgang Herms, Michael Willem, Christian Haass, , Sabina Tahirović

This study identifies proteomic changes in microglia during Alzheimer's disease progression in mouse models, showing fibrillar Aβ drives microglial dysfunction.

eLife · Jun 8, 2020Peer-reviewedNeuroscience