Regulation of Pacemaker Current in the Sinoatrial Node by Zonula Occludens-1
Rui Zhang, Sarah Teboull, Dexin Chen, Pexin He, Seho Kim, Liang Li, Daniel Adolfo, Terence W. Gee, Robert S. Ross, Joshua I. Goldhaber
This study investigates the role of ZO-1 in sinoatrial node automaticity and finds that its loss reduces pacemaker current and impairs atrial conduction, leading to bradyarrhythmia.
bioRxiv · May 21, 2026 · PreprintPhysiology