Daniel Diaz

Oncogenic transformation proceeds through a transient state of cellular plasticity constrained by lineage-specific barriers.

This paper investigates why oncogenic mutations often fail to induce cancer by showing that normal cells undergo a transient, plastic state but are constrained by lineage-specific barriers preventing stable transformation.

High sensitivity single cell RNA sequencing with split pool barcoding

This paper introduces an improved combinatorial barcoding method for scRNA-seq that significantly increases sensitivity, detecting more transcripts and genes per cell across various sample types.