Author

Sarah Schroeder

University of California San Diego

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Genetic & Genomic Medicine· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:scRNA-seq· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Efthymia PapalexiiD· 3 shared Maria Nigos· 3 shared Ryan T. KoehleriD· 3 shared Vuong TraniD· 3 shared Ajay Sapre· 2 shared Alexander Rosenberg· 2 shared Bryan HariadiiD· 2 shared Charles Roco· 2 shared

Activity by Year

2022-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Efthymia PapalexiORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A single-cell cytokine dictionary of human peripheral blood

Fabian Joachim Theis, Lukas Oesinghaus, Sören Becker, Larsen Vornholz, Efthymia Papalexi, Joey Pangallo, Amir Moinfar, Jenni Liu, Alyssa La Fleur, Maiia Shulman, Simone Marrujo, Bryan Hariadi, Crina Curca, Alexa Suyama, Maria Nigos, , Georg Seelig

The paper creates a Human Cytokine Dictionary using single-cell transcriptomes of PBMCs stimulated with cytokines, revealing cell-type-specific responses and communication networks.

bioRxiv · Dec 15, 2025 · PreprintImmunology

The contribution of de novo coding mutations to meningomyelocele

Yoo-Jin Jiny Ha, Ashna Nisal, Isaac Tang, Chanjae Lee, Ishani Jhamb, Cassidy Wallace, Robyn E. Howarth, Sarah Schroeder, Keng Ioi Vong, Naomi Meave Ojeda, Fiza Jiwani, Chelsea Barrows, Sangmoon Lee, Nan Jiang, Arzoo M. Patel, , Joseph G. Gleeson

The paper identifies de novo mutations contributing to meningomyelocele risk by analyzing trios and finding damaging mutations in 22.3% of cases.

Nature · Mar 26, 2025Peer-reviewedGenetic & Genomic Medicine

Tahoe-100M: A Giga-Scale Single-Cell Perturbation Atlas for Context-Dependent Gene Function and Cellular Modeling

Jesse M. Zhang, Airol A. Ubas, Richard de Borja, Valentine Svensson, Nicole Thomas, Neha Thakar, Ian K. Lai, Aidan F. Winters, Umair Khan, Matthew G. Jones, John D. Thompson, Vuong Tran, Joseph Pangallo, Efthymia Papalexi, Ajay Sapre, , Johnny X. Yu

A 100-million-cell atlas: 50 cancer lines pooled as spheroid villages, treated with 379 drugs at several doses, profiled by combinatorial-barcoding scRNA-seq and embedded with a 10-dimensional scVI model.

bioRxiv · Feb 20, 2025 · PreprintGenomics✦ In-depth digest

High sensitivity single cell RNA sequencing with split pool barcoding

Vuong Tran, Efthymia Papalexi, Sarah Schroeder, Grace S. Kim, Ajay A. Sapre, Joey Pangallo, Alex Sova, Peter Matulich, Lauren Kenyon, Zeynep Sayar, Ryan T. Koehler, Daniel Diaz, Archita Gadkari, Kamy J. Howitz, Maria Nigos, , Alexander B. Rosenberg

This paper introduces an improved combinatorial barcoding method for scRNA-seq that significantly increases sensitivity, detecting more transcripts and genes per cell across various sample types.

bioRxiv · Aug 27, 2022 · PreprintGenomics