The fungal ligand chitin directly binds and signals inflammation dependent on oligomer size and TLR2
Katharina Fuchs, Yamel Cardona Gloria, Olaf-Oliver Wolz, Franziska Herster, Lokesh Sharma, Carly Dillen, Christoph Täumer, Sabine Dickhöfer, Zsofia Bittner, Truong-Minh Dang, Anurag Singh, Daniel Haischer, Maria A. Schlöffel, Kirsten J. Koymans, Tharmila Sanmuganantham, , Alexander N.R. Weber
This study identifies chitin oligomers as the smallest immunologically active motif and TLR2 as the primary receptor for chitin, showing size-dependent signaling and therapeutic potential.
bioRxiv · Mar 5, 2018 · PreprintImmunology