A conserved role of Hippo signaling in initiation of the first lineage specification event across mammals
Claudia Gerri, Afshan McCarthy, Gwen Mei Scott, Marius Regin, Anna Sophie Brumm, Claire S. Simon, Janet S. Lee, Cristina Montesinos, Caroline Hassitt, Sarah Hockenhull, Daniel Hampshire, Kay T. Elder, Phil Snell, Leila Christie, Ali Akbar Fouladi-Nashta, , Kathy K. Niakan
The paper investigates the conservation of Hippo signaling in the first lineage specification event across four mammalian species, finding that inhibiting the Hippo pathway drives ectopic trophectoderm initiation in all species.
bioRxiv · Jul 1, 2022 · PreprintDevelopmental Biology