Daniel T. Abebe

Reducing methylation of histone 3.3 lysine 4 in the medial ganglionic eminence and hypothalamus recapitulates neurodevelopmental disorder phenotypes

This study shows that reducing H3K4 methylation in specific brain regions causes neurodevelopmental disorder-like phenotypes, including seizures, growth issues, and behavioral deficits.

Neurotrophic Factor-α1/carboxypeptidase E regulates critical protein networks to rescue neurodegeneration, defective synaptogenesis and impaired autophagy in Alzheimer's Disease mice

This paper investigates the effects of NF-1/CPE gene therapy in AD mice, finding it prevents memory loss and reverses pathology by modulating protein networks involved in synaptogenesis, autophagy, and tau/Aβ accumulation.

Complex opioid driven modulation of glutamatergic and cholinergic neurotransmission in a GABAergic brain nucleus associated with emotion, reward and addiction.

This study investigates how opioid receptors modulate glutamatergic and cholinergic neurotransmission in the medial habenula/interpeduncular nucleus circuit, revealing complex developmental regulation and interactions with potassium channels.

Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution.

The paper shows that eGlyRs in hippocampal interneurons regulate network activity through developmental and evolutionary conserved mechanisms.

IRF8 deficiency causes anxiety-like behavior in a sex-dependent manner

This study shows that IRF8 deficiency in microglia causes anxiety-like behavior in female mice but not males, with redox dysregulation involved.

Mature interneuron subtypes arise from distinct spatial and temporal subdomains within the caudal ganglionic eminence

The paper investigates the spatial and temporal origins of interneuron subtypes in the caudal ganglionic eminence (CGE) and shows that specific subtypes arise from distinct CGE subdomains with stable spatial biases over time.

Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development

The paper shows that opioids suppress inhibition in hippocampal PV-INs but not neocortex across species and development, highlighting conserved and divergent roles in neural circuits.